The evolution of IL-4 and IL-13 and their receptor subunits

Tiehui Wang; Christopher J. Secombes

doi:10.1016/j.cyto.2015.04.012

The evolution of IL-4 and IL-13 and their receptor subunits

Tiehui Wang, Christopher J. Secombes^* (Corresponding Author)

^*Corresponding author for this work

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Abstract

This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.

Original language	English
Pages (from-to)	8-13
Number of pages	6
Journal	Cytokine
Volume	75
Issue number	1
Early online date	21 May 2015
DOIs	https://doi.org/10.1016/j.cyto.2015.04.012
Publication status	Published - Sept 2015

Keywords

IL-4/IL-13 evolution
IL-4R/IL-13R receptor evolution
IL-4/13 molecules

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The evolution of IL-4 and IL-13 and their receptor subunits
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abstract = "This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.",

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The evolution of IL-4 and IL-13 and their receptor subunits

Abstract

Keywords

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