The evolution of IL-4 and IL-13 and their receptor subunits

Tiehui Wang; Christopher J. Secombes

doi:10.1016/j.cyto.2015.04.012

The evolution of IL-4 and IL-13 and their receptor subunits

Tiehui Wang, Christopher J. Secombes^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

7 Downloads (Pure)

Abstract

This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.

Original language	English
Pages (from-to)	8-13
Number of pages	6
Journal	Cytokine
Volume	75
Issue number	1
Early online date	21 May 2015
DOIs	https://doi.org/10.1016/j.cyto.2015.04.012
Publication status	Published - Sep 2015

Keywords

IL-4/IL-13 evolution
IL-4R/IL-13R receptor evolution
IL-4/13 molecules

Access to Document

10.1016/j.cyto.2015.04.012Licence: Unspecified

The evolution of IL-4 and IL-13 and their receptor subunits
This manuscript is distributed in accordance with the Creative Commons Attribution Non Commercial-No Derivs (CC BY-NC-ND 4.0) license, which permits others to distribute this work non-commercially provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 532 KB

Cite this

@article{b55a04b546624c6eabd260aa492adc9b,

title = "The evolution of IL-4 and IL-13 and their receptor subunits",

abstract = "This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.",

keywords = "IL-4/IL-13 evolution, IL-4R/IL-13R receptor evolution, IL-4/13 molecules",

author = "Tiehui Wang and Secombes, {Christopher J.}",

year = "2015",

month = sep,

doi = "10.1016/j.cyto.2015.04.012",

language = "English",

volume = "75",

pages = "8--13",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - The evolution of IL-4 and IL-13 and their receptor subunits

AU - Wang, Tiehui

AU - Secombes, Christopher J.

PY - 2015/9

Y1 - 2015/9

N2 - This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.

AB - This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.

KW - IL-4/IL-13 evolution

KW - IL-4R/IL-13R receptor evolution

KW - IL-4/13 molecules

U2 - 10.1016/j.cyto.2015.04.012

DO - 10.1016/j.cyto.2015.04.012

M3 - Article

VL - 75

SP - 8

EP - 13

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 1

ER -

The evolution of IL-4 and IL-13 and their receptor subunits

Abstract

Keywords

Access to Document

Fingerprint

Cite this