This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.
|Number of pages||6|
|Early online date||21 May 2015|
|Publication status||Published - Sep 2015|
- IL-4/IL-13 evolution
- IL-4R/IL-13R receptor evolution
- IL-4/13 molecules