The evolution of spliced leader trans-splicing in nematodes

Jonathan Pettitt; Neale Harrison; Ian Stansfield; Bernadette Connolly; Berndt Müller

doi:10.1042/BST0381125

The evolution of spliced leader trans-splicing in nematodes

Jonathan Pettitt, Neale Harrison, Ian Stansfield, Bernadette Connolly, Berndt Müller

Medical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Spliced leader trans-splicing occurs in many primitive eukaryotes including nematodes. Most of our knowledge of trans-splicing in nematodes stems from the model organism Caenorhabditis elegans and relatives, and from work with Ascaris. Our investigation of spliced leader trans-splicing in distantly related Dorylaimia nematodes indicates that spliced-leader trans-splicing arose before the nematode phylum and suggests that the spliced leader RNA gene complements in extant nematodes have evolved from a common ancestor with a diverse set of spliced leader RNA genes.

Original language	English
Pages (from-to)	1125-1130
Number of pages	6
Journal	Biochemical Society Transactions
Volume	38
Issue number	4
DOIs	https://doi.org/10.1042/BST0381125
Publication status	Published - Aug 2010

Keywords

animals
base sequence
evolution, molecular
models, biological
molecular sequence data
nematoda
nucleic acid conformation
phylogeny
RNA splice sites
RNA, spliced leader
trans-splicing

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10.1042/BST0381125

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abstract = "Spliced leader trans-splicing occurs in many primitive eukaryotes including nematodes. Most of our knowledge of trans-splicing in nematodes stems from the model organism Caenorhabditis elegans and relatives, and from work with Ascaris. Our investigation of spliced leader trans-splicing in distantly related Dorylaimia nematodes indicates that spliced-leader trans-splicing arose before the nematode phylum and suggests that the spliced leader RNA gene complements in extant nematodes have evolved from a common ancestor with a diverse set of spliced leader RNA genes.",

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AU - Harrison, Neale

AU - Stansfield, Ian

AU - Connolly, Bernadette

AU - Müller, Berndt

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AB - Spliced leader trans-splicing occurs in many primitive eukaryotes including nematodes. Most of our knowledge of trans-splicing in nematodes stems from the model organism Caenorhabditis elegans and relatives, and from work with Ascaris. Our investigation of spliced leader trans-splicing in distantly related Dorylaimia nematodes indicates that spliced-leader trans-splicing arose before the nematode phylum and suggests that the spliced leader RNA gene complements in extant nematodes have evolved from a common ancestor with a diverse set of spliced leader RNA genes.

KW - animals

KW - base sequence

KW - evolution, molecular

KW - models, biological

KW - molecular sequence data

KW - nematoda

KW - nucleic acid conformation

KW - phylogeny

KW - RNA splice sites

KW - RNA, spliced leader

KW - trans-splicing

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SP - 1125

EP - 1130

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

The evolution of spliced leader trans-splicing in nematodes

Abstract

Keywords

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