The Fetus as an Allograft: evidence for protective antibodies to HLA-linked paternal antigens

D A  POWER; R J  MASON; G M  STEWART; G R D  CATTO; Alison Murray MacLeod; Keith Nicol Stewart; W G  SHEWAN

doi:10.1016/S0140-6736(83)92246-8

The Fetus as an Allograft: evidence for protective antibodies to HLA-linked paternal antigens

D A POWER, R J MASON, G M STEWART, G R D CATTO, Alison Murray MacLeod, Keith Nicol Stewart, W G SHEWAN

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Abstract

Non-cytotoxic antibodies to paternal B lymphocytes were detected in sera from 11 of 11 multiparous women and from 11 of 16 normal primigravidae during the first trimester of pregnancy. These antibodies were not, however, detected in sera from 9 of 10 women of comparable gestation at the time of spontaneous abortion. By means of a rosette inhibition assay, the difference in antibody activity between the primigravidae (mean 37·9±19%, median 36·5%) and the women subject to spontaneous abortion (mean 7·3±11·6%, median 0%) was statistically significant. This antibody activity was not directed to the known HLA specificities (HLA-A, B, C, or DR), but linkage to the HLA gene complex was suggested by family studies. These results provide evidence for an HLA-linked antigen system not defined by conventional tissue-typing techniques. Fetomaternal disparity at this antigenic site may be important for successful pregnancy.

Original language	English
Pages (from-to)	701-704
Number of pages	4
Journal	The Lancet
Volume	2
Issue number	8352
DOIs	https://doi.org/10.1016/S0140-6736(83)92246-8
Publication status	Published - 24 Sep 1983

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title = "The Fetus as an Allograft: evidence for protective antibodies to HLA-linked paternal antigens",

abstract = "Non-cytotoxic antibodies to paternal B lymphocytes were detected in sera from 11 of 11 multiparous women and from 11 of 16 normal primigravidae during the first trimester of pregnancy. These antibodies were not, however, detected in sera from 9 of 10 women of comparable gestation at the time of spontaneous abortion. By means of a rosette inhibition assay, the difference in antibody activity between the primigravidae (mean 37·9±19%, median 36·5%) and the women subject to spontaneous abortion (mean 7·3±11·6%, median 0%) was statistically significant. This antibody activity was not directed to the known HLA specificities (HLA-A, B, C, or DR), but linkage to the HLA gene complex was suggested by family studies. These results provide evidence for an HLA-linked antigen system not defined by conventional tissue-typing techniques. Fetomaternal disparity at this antigenic site may be important for successful pregnancy. ",

author = "POWER, {D A} and MASON, {R J} and STEWART, {G M} and CATTO, {G R D} and MacLeod, {Alison Murray} and Stewart, {Keith Nicol} and SHEWAN, {W G}",

year = "1983",

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doi = "10.1016/S0140-6736(83)92246-8",

language = "English",

volume = "2",

pages = "701--704",

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TY - JOUR

T1 - The Fetus as an Allograft

T2 - evidence for protective antibodies to HLA-linked paternal antigens

AU - POWER, D A

AU - MASON, R J

AU - STEWART, G M

AU - CATTO, G R D

AU - MacLeod, Alison Murray

AU - Stewart, Keith Nicol

AU - SHEWAN, W G

PY - 1983/9/24

Y1 - 1983/9/24

N2 - Non-cytotoxic antibodies to paternal B lymphocytes were detected in sera from 11 of 11 multiparous women and from 11 of 16 normal primigravidae during the first trimester of pregnancy. These antibodies were not, however, detected in sera from 9 of 10 women of comparable gestation at the time of spontaneous abortion. By means of a rosette inhibition assay, the difference in antibody activity between the primigravidae (mean 37·9±19%, median 36·5%) and the women subject to spontaneous abortion (mean 7·3±11·6%, median 0%) was statistically significant. This antibody activity was not directed to the known HLA specificities (HLA-A, B, C, or DR), but linkage to the HLA gene complex was suggested by family studies. These results provide evidence for an HLA-linked antigen system not defined by conventional tissue-typing techniques. Fetomaternal disparity at this antigenic site may be important for successful pregnancy.

AB - Non-cytotoxic antibodies to paternal B lymphocytes were detected in sera from 11 of 11 multiparous women and from 11 of 16 normal primigravidae during the first trimester of pregnancy. These antibodies were not, however, detected in sera from 9 of 10 women of comparable gestation at the time of spontaneous abortion. By means of a rosette inhibition assay, the difference in antibody activity between the primigravidae (mean 37·9±19%, median 36·5%) and the women subject to spontaneous abortion (mean 7·3±11·6%, median 0%) was statistically significant. This antibody activity was not directed to the known HLA specificities (HLA-A, B, C, or DR), but linkage to the HLA gene complex was suggested by family studies. These results provide evidence for an HLA-linked antigen system not defined by conventional tissue-typing techniques. Fetomaternal disparity at this antigenic site may be important for successful pregnancy.

U2 - 10.1016/S0140-6736(83)92246-8

DO - 10.1016/S0140-6736(83)92246-8

M3 - Article

VL - 2

SP - 701

EP - 704

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8352

ER -

The Fetus as an Allograft: evidence for protective antibodies to HLA-linked paternal antigens

Abstract

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