The fluorinase from Streptomyces cattleya is also a chlorinase

Hai Deng, Steven L. Cobb, Andrew R McEwan, Ryan P. McGlinchey, James H. Naismith, David O'hagan (Corresponding Author), David A. Robinson, Jonathan B Spencer

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a CF bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalAngewandte Chemie International Edition
Volume45
Issue number5
Early online date21 Dec 2005
DOIs
Publication statusPublished - 23 Jan 2006

Keywords

  • chlorinase
  • enzyme catalysis
  • fluorinase
  • halogenation
  • S‐adenosylmethionine

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