The fluorinase from Streptomyces cattleya is also a chlorinase

Hai Deng, Steven L. Cobb, Andrew R McEwan, Ryan P. McGlinchey, James H. Naismith, David O'hagan (Corresponding Author), David A. Robinson, Jonathan B Spencer

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a CF bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalAngewandte Chemie International Edition
Volume45
Issue number5
Early online date21 Dec 2005
DOIs
Publication statusPublished - 23 Jan 2006

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Chlorination
Ions
Fluorides
Enzymes
Chlorides
fluorinase

Keywords

  • chlorinase
  • enzyme catalysis
  • fluorinase
  • halogenation
  • S‐adenosylmethionine

Cite this

Deng, H., Cobb, S. L., McEwan, A. R., McGlinchey, R. P., Naismith, J. H., O'hagan, D., ... Spencer, J. B. (2006). The fluorinase from Streptomyces cattleya is also a chlorinase. Angewandte Chemie International Edition, 45(5), 759-762. https://doi.org/10.1002/anie.200503582

The fluorinase from Streptomyces cattleya is also a chlorinase. / Deng, Hai; Cobb, Steven L. ; McEwan, Andrew R; McGlinchey, Ryan P.; Naismith, James H.; O'hagan, David (Corresponding Author); Robinson, David A.; Spencer, Jonathan B.

In: Angewandte Chemie International Edition, Vol. 45, No. 5, 23.01.2006, p. 759-762.

Research output: Contribution to journalArticle

Deng, H, Cobb, SL, McEwan, AR, McGlinchey, RP, Naismith, JH, O'hagan, D, Robinson, DA & Spencer, JB 2006, 'The fluorinase from Streptomyces cattleya is also a chlorinase', Angewandte Chemie International Edition, vol. 45, no. 5, pp. 759-762. https://doi.org/10.1002/anie.200503582
Deng, Hai ; Cobb, Steven L. ; McEwan, Andrew R ; McGlinchey, Ryan P. ; Naismith, James H. ; O'hagan, David ; Robinson, David A. ; Spencer, Jonathan B. / The fluorinase from Streptomyces cattleya is also a chlorinase. In: Angewandte Chemie International Edition. 2006 ; Vol. 45, No. 5. pp. 759-762.
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