The Function of Fish Cytokines

Jun Zou; Christopher J. Secombes

doi:10.3390/biology5020023

The Function of Fish Cytokines

Jun Zou, Christopher J. Secombes

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431 Citations (Scopus)

14 Downloads (Pure)

Abstract

What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have focused on the induced effects of cytokine recombinant proteins, or have used loss- and gain-of-function experiments in zebrafish. Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines. This knowledge will aid our ability to determine and modulate the pathways leading to protective immunity, to improve fish health in aquaculture.

Original language	English
Article number	23
Pages (from-to)	1-35
Number of pages	35
Journal	Biology
Volume	5
Issue number	2
DOIs	https://doi.org/10.3390/biology5020023
Publication status	Published - 24 May 2016

Keywords

cytokines
bioactivity
recombinant proteins
loss- and gain-of-function
interleukins
interferons
colony stimulating factors
tumour necrosis factors
transforming growth factor-β

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10.3390/biology5020023Licence: CC BY

The Function of Fish Cytokines
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 780 KBLicence: CC BY

Cite this

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KW - tumour necrosis factors

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The Function of Fish Cytokines

Abstract

Keywords

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