The Function of Fish Cytokines

Jun Zou, Christopher J. Secombes

Research output: Contribution to journalArticlepeer-review

316 Citations (Scopus)
11 Downloads (Pure)


What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have focused on the induced effects of cytokine recombinant proteins, or have used loss- and gain-of-function experiments in zebrafish. Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines. This knowledge will aid our ability to determine and modulate the pathways leading to protective immunity, to improve fish health in aquaculture.
Original languageEnglish
Article number23
Pages (from-to)1-35
Number of pages35
Issue number2
Publication statusPublished - 24 May 2016


  • cytokines
  • bioactivity
  • recombinant proteins
  • loss- and gain-of-function
  • interleukins
  • interferons
  • colony stimulating factors
  • tumour necrosis factors
  • transforming growth factor-β


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