THE FUNCTIONAL-ROLE OF EXCITATORY AND INHIBITORY INTERACTIONS IN CHOPPER CELLS OF THE ANTEROVENTRAL COCHLEAR NUCLEUS

Y C LAI, R L WINSLOW, M B SACHS, Ying-Cheng Lai

Research output: Contribution to journalArticle

Abstract

Chopper cells in the anteroventral cochlear nucleus of the cat maintain a robust rate-place representation of vowel spectra over a broad range of stimulus levels. This representation resembles that of low threshold, high spontaneous rate primary auditory nerve fibers at low stimulus levels, and that of high threshold, low spontaneous rate auditory-nerve fibers at high stimulus levels. This has led to the hypothesis that chopper cells in the anteroventral cochlear nucleus selectively process inputs from different spontaneous rate populations of primary auditory-nerve fibers at different stimulus levels. We present a computational model, making use of shunting inhibition, for how this level dependent processing may be performed within the chopper cell dendritic tree. We show that this model (1) implements level-dependent selective processing, (2) reproduces detailed features of real chopper cell post-stimulus-time histograms, and (3) reproduces nonmonotonic rate versus level functions in response to single tones measured.

Original languageEnglish
Pages (from-to)1127-1140
Number of pages14
JournalNeural computation
Volume6
Issue number6
Publication statusPublished - Nov 1994

Keywords

  • AUDITORY-NERVE FIBERS
  • LEVEL FUNCTIONS
  • REGULARITY
  • CLASSIFICATION
  • RESPONSES
  • PATTERNS
  • NEURONS
  • SLICES
  • UNITS

Cite this

THE FUNCTIONAL-ROLE OF EXCITATORY AND INHIBITORY INTERACTIONS IN CHOPPER CELLS OF THE ANTEROVENTRAL COCHLEAR NUCLEUS. / LAI, Y C ; WINSLOW, R L ; SACHS, M B ; Lai, Ying-Cheng.

In: Neural computation, Vol. 6, No. 6, 11.1994, p. 1127-1140.

Research output: Contribution to journalArticle

LAI, Y C ; WINSLOW, R L ; SACHS, M B ; Lai, Ying-Cheng. / THE FUNCTIONAL-ROLE OF EXCITATORY AND INHIBITORY INTERACTIONS IN CHOPPER CELLS OF THE ANTEROVENTRAL COCHLEAR NUCLEUS. In: Neural computation. 1994 ; Vol. 6, No. 6. pp. 1127-1140.
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AB - Chopper cells in the anteroventral cochlear nucleus of the cat maintain a robust rate-place representation of vowel spectra over a broad range of stimulus levels. This representation resembles that of low threshold, high spontaneous rate primary auditory nerve fibers at low stimulus levels, and that of high threshold, low spontaneous rate auditory-nerve fibers at high stimulus levels. This has led to the hypothesis that chopper cells in the anteroventral cochlear nucleus selectively process inputs from different spontaneous rate populations of primary auditory-nerve fibers at different stimulus levels. We present a computational model, making use of shunting inhibition, for how this level dependent processing may be performed within the chopper cell dendritic tree. We show that this model (1) implements level-dependent selective processing, (2) reproduces detailed features of real chopper cell post-stimulus-time histograms, and (3) reproduces nonmonotonic rate versus level functions in response to single tones measured.

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KW - LEVEL FUNCTIONS

KW - REGULARITY

KW - CLASSIFICATION

KW - RESPONSES

KW - PATTERNS

KW - NEURONS

KW - SLICES

KW - UNITS

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