The fungal microbiota of de-novo paediatric inflammatory bowel disease

I. Mukhopadhya; R. Hansen; C. Meharg; J. M. Thomson; R. K. Russell; S. H. Berry; E. M. El-Omar; G. L. Hold

doi:10.1016/j.micinf.2014.12.001

The fungal microbiota of de-novo paediatric inflammatory bowel disease

I. Mukhopadhya, R. Hansen, C. Meharg, J. M. Thomson, R. K. Russell, S. H. Berry, E. M. El-Omar, G. L. Hold^*

^*Corresponding author for this work

Research output: Contribution to journal › Article

33 Citations (Scopus)

5 Downloads (Pure)

Abstract

Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

Original language	English
Pages (from-to)	304-310
Number of pages	7
Journal	Microbes and Infection
Volume	17
Issue number	4
Early online date	15 Dec 2014
DOIs	https://doi.org/10.1016/j.micinf.2014.12.001
Publication status	Published - Apr 2015

Keywords

fungal microbiota
paediatric inflammatory bowel disease
gut microbiota
Crohns-disease
ulcerative-colitis
candida-albicans
diversity
bacterial
flora

Access to Document

10.1016/j.micinf.2014.12.001Licence: CC BY-NC-ND

The fungal microbiota of de-novo paediatric inflammatory bowel disease
© 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Final published version, 999 KBLicence: CC BY-NC-ND

Profiles

Indrani Mukhopadhya

School of Medicine, Medical Sciences & Nutrition, The Rowett Institute of Nutrition and Health - Research Fellow

Person: Academic Related - Research

Cite this

Mukhopadhya, I., Hansen, R., Meharg, C., Thomson, J. M., Russell, R. K., Berry, S. H., El-Omar, E. M., & Hold, G. L. (2015). The fungal microbiota of de-novo paediatric inflammatory bowel disease. Microbes and Infection, 17(4), 304-310. https://doi.org/10.1016/j.micinf.2014.12.001

@article{c40ad37061474abc9c8194ed13b0e836,

title = "The fungal microbiota of de-novo paediatric inflammatory bowel disease",

abstract = "Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.",

keywords = "fungal microbiota, paediatric inflammatory bowel disease, gut microbiota, Crohns-disease, ulcerative-colitis, candida-albicans, diversity, bacterial, flora",

author = "I. Mukhopadhya and R. Hansen and C. Meharg and Thomson, {J. M.} and Russell, {R. K.} and Berry, {S. H.} and El-Omar, {E. M.} and Hold, {G. L.}",

note = "Date of Acceptance:01/12/2014 Acknowledgements We are grateful for the expertise of our sequencing provider NewGene. We appreciate the generosity of the families who freely gave their time and samples to make this study possible and the theatre staff of all centres who allowed time for sample collection during busy endoscopy lists. This work was funded by a Clinical Academic Training Fellowship from the Chief Scientist Office in Scotland (CAF/08/01) which also funded the salary of RH, the Broad Medical Research programme and a project grant from NHS Grampian Endowments. The Yorkhill IBD team is generously supported by the Catherine McEwan Foundation and the Yorkhill IBD fund. RKR is supported by an NHS research Scotland fellowship. RKR has received support from a Medical Research Council (MRC) patient research cohorts initiative grant (G0800675) for PICTS. ",

year = "2015",

month = apr,

doi = "10.1016/j.micinf.2014.12.001",

language = "English",

volume = "17",

pages = "304--310",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "4",

}

TY - JOUR

T1 - The fungal microbiota of de-novo paediatric inflammatory bowel disease

AU - Mukhopadhya, I.

AU - Hansen, R.

AU - Meharg, C.

AU - Thomson, J. M.

AU - Russell, R. K.

AU - Berry, S. H.

AU - El-Omar, E. M.

AU - Hold, G. L.

N1 - Date of Acceptance:01/12/2014 Acknowledgements We are grateful for the expertise of our sequencing provider NewGene. We appreciate the generosity of the families who freely gave their time and samples to make this study possible and the theatre staff of all centres who allowed time for sample collection during busy endoscopy lists. This work was funded by a Clinical Academic Training Fellowship from the Chief Scientist Office in Scotland (CAF/08/01) which also funded the salary of RH, the Broad Medical Research programme and a project grant from NHS Grampian Endowments. The Yorkhill IBD team is generously supported by the Catherine McEwan Foundation and the Yorkhill IBD fund. RKR is supported by an NHS research Scotland fellowship. RKR has received support from a Medical Research Council (MRC) patient research cohorts initiative grant (G0800675) for PICTS.

PY - 2015/4

Y1 - 2015/4

N2 - Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

AB - Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

KW - fungal microbiota

KW - paediatric inflammatory bowel disease

KW - gut microbiota

KW - Crohns-disease

KW - ulcerative-colitis

KW - candida-albicans

KW - diversity

KW - bacterial

KW - flora

U2 - 10.1016/j.micinf.2014.12.001

DO - 10.1016/j.micinf.2014.12.001

M3 - Article

VL - 17

SP - 304

EP - 310

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 4

ER -