The fungal microbiota of de-novo paediatric inflammatory bowel disease

I. Mukhopadhya, R. Hansen, C. Meharg, J. M. Thomson, R. K. Russell, S. H. Berry, E. M. El-Omar, G. L. Hold*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)
3 Downloads (Pure)

Abstract

Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

Original languageEnglish
Pages (from-to)304-310
Number of pages7
JournalMicrobes and Infection
Volume17
Issue number4
Early online date15 Dec 2014
DOIs
Publication statusPublished - Apr 2015

Keywords

  • fungal microbiota
  • paediatric inflammatory bowel disease
  • gut microbiota
  • Crohns-disease
  • ulcerative-colitis
  • candida-albicans
  • diversity
  • bacterial
  • flora

Cite this