@article{c40ad37061474abc9c8194ed13b0e836,
title = "The fungal microbiota of de-novo paediatric inflammatory bowel disease",
abstract = "Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.",
keywords = "fungal microbiota, paediatric inflammatory bowel disease, gut microbiota, Crohns-disease, ulcerative-colitis, candida-albicans, diversity, bacterial, flora",
author = "I. Mukhopadhya and R. Hansen and C. Meharg and Thomson, {J. M.} and Russell, {R. K.} and Berry, {S. H.} and El-Omar, {E. M.} and Hold, {G. L.}",
note = "Date of Acceptance:01/12/2014 Acknowledgements We are grateful for the expertise of our sequencing provider NewGene. We appreciate the generosity of the families who freely gave their time and samples to make this study possible and the theatre staff of all centres who allowed time for sample collection during busy endoscopy lists. This work was funded by a Clinical Academic Training Fellowship from the Chief Scientist Office in Scotland (CAF/08/01) which also funded the salary of RH, the Broad Medical Research programme and a project grant from NHS Grampian Endowments. The Yorkhill IBD team is generously supported by the Catherine McEwan Foundation and the Yorkhill IBD fund. RKR is supported by an NHS research Scotland fellowship. RKR has received support from a Medical Research Council (MRC) patient research cohorts initiative grant (G0800675) for PICTS.",
year = "2015",
month = "4",
doi = "10.1016/j.micinf.2014.12.001",
language = "English",
volume = "17",
pages = "304--310",
journal = "Microbes and Infection",
issn = "1286-4579",
publisher = "Elsevier Masson SAS",
number = "4",
}