The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

Cristal Huysamen, Gordon D Brown

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the 'Dectin-1 cluster' of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.
Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalFEMS Microbiology Letters
Volume290
Issue number2
Early online date20 Nov 2008
DOIs
Publication statusPublished - Jan 2009

Fingerprint

C-Type Lectins
Pattern Recognition Receptors
Ligands
Myeloid Cells
Genes
Immunity
Homeostasis
dectin 1

Keywords

  • animals
  • fungi
  • humans
  • lectins, C-type
  • membrane proteins
  • mycoses
  • nerve tissue proteins
  • receptors, mitogen
  • receptors, pattern recognition
  • C-type lectin
  • myeloid cells
  • ITAM
  • ITIM
  • signaling
  • homeostasis

Cite this

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. / Huysamen, Cristal; Brown, Gordon D.

In: FEMS Microbiology Letters, Vol. 290, No. 2, 01.2009, p. 121-128.

Research output: Contribution to journalArticle

@article{654ad968273c4e8a9b4e7933c0357fd0,
title = "The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors",
abstract = "The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the 'Dectin-1 cluster' of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.",
keywords = "animals, fungi, humans, lectins, C-type, membrane proteins, mycoses, nerve tissue proteins, receptors, mitogen, receptors, pattern recognition, C-type lectin, myeloid cells, ITAM, ITIM, signaling, homeostasis",
author = "Cristal Huysamen and Brown, {Gordon D}",
year = "2009",
month = "1",
doi = "10.1111/j.1574-6968.2008.01418.x",
language = "English",
volume = "290",
pages = "121--128",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

AU - Huysamen, Cristal

AU - Brown, Gordon D

PY - 2009/1

Y1 - 2009/1

N2 - The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the 'Dectin-1 cluster' of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.

AB - The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the 'Dectin-1 cluster' of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.

KW - animals

KW - fungi

KW - humans

KW - lectins, C-type

KW - membrane proteins

KW - mycoses

KW - nerve tissue proteins

KW - receptors, mitogen

KW - receptors, pattern recognition

KW - C-type lectin

KW - myeloid cells

KW - ITAM

KW - ITIM

KW - signaling

KW - homeostasis

U2 - 10.1111/j.1574-6968.2008.01418.x

DO - 10.1111/j.1574-6968.2008.01418.x

M3 - Article

C2 - 19025564

VL - 290

SP - 121

EP - 128

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 2

ER -