The genetic basis of the fitness costs of antimicrobial resistance : a meta-analysis approach

Tom Vogwill*, R. Craig Maclean

*Corresponding author for this work

Research output: Contribution to journalArticle

120 Citations (Scopus)
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Abstract

The evolution of antibiotic resistance carries a fitness cost, expressed in terms of reduced competitive ability in the absence of antibiotics. This cost plays a key role in the dynamics of resistance by generating selection against resistance when bacteria encounter an antibiotic-free environment. Previous work has shown that the cost of resistance is highly variable, but the underlying causes remain poorly understood. Here, we use a meta-analysis of the published resistance literature to determine how the genetic basis of resistance influences its cost. We find that on average chromosomal resistance mutations carry a larger cost than acquiring resistance via a plasmid. This may explain why resistance often evolves by plasmid acquisition. Second, we find that the cost of plasmid acquisition increases with the breadth of its resistance range. This suggests a potentially important limit on the evolution of extensive multidrug resistance via plasmids. We also find that epistasis can significantly alter the cost of mutational resistance. Overall, our study shows that the cost of antimicrobial resistance can be partially explained by its genetic basis. It also highlights both the danger associated with plasmidborne resistance and the need to understand why resistance plasmids carry a relatively low cost.

Original languageEnglish
Pages (from-to)284-295
Number of pages12
JournalEvolutionary Applications
Volume8
Issue number3
Early online date12 Dec 2014
DOIs
Publication statusPublished - Mar 2015

Keywords

  • Adaptation
  • Antibiotic resistance
  • Antimicrobial resistance
  • Fitness cost
  • Microbes
  • Mutation
  • Plasmid

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