The genetic portrait of an outbreak strain

Hasan Yesilkaya; Ken J. Forbes; Jamila Shafi; Rebecca Smith; Jeremy W Dale; Kumar Rajakumar; Michael R. Barer; Peter W. Andrew

doi:10.1016/j.tube.2005.08.019

The genetic portrait of an outbreak strain

Hasan Yesilkaya, Ken J. Forbes, Jamila Shafi, Rebecca Smith, Jeremy W Dale, Kumar Rajakumar, Michael R. Barer, Peter W. Andrew

Applied Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	357-362
Number of pages	6
Journal	Tuberculosis
Volume	86
Issue number	5
DOIs	https://doi.org/10.1016/j.tube.2005.08.019
Publication status	Published - Sept 2006

Keywords

Mycobacterium tuberculosis
CH strain
outbreak
insertion
deletion
IS6110
mycobacterium-tuberculosis complex
nucleotide polymorphisms
clinical isolate
immune-response
virulence
genomes
infection
macrophages
mutagenesis
organisms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2005.08.019

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title = "The genetic portrait of an outbreak strain",

abstract = "Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed. (c) 2005 Elsevier Ltd. All rights reserved.",

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T1 - The genetic portrait of an outbreak strain

AU - Yesilkaya, Hasan

AU - Forbes, Ken J.

AU - Shafi, Jamila

AU - Smith, Rebecca

AU - Dale, Jeremy W

AU - Rajakumar, Kumar

AU - Barer, Michael R.

AU - Andrew, Peter W.

PY - 2006/9

Y1 - 2006/9

N2 - Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed. (c) 2005 Elsevier Ltd. All rights reserved.

KW - Mycobacterium tuberculosis

KW - CH strain

KW - outbreak

KW - insertion

KW - deletion

KW - IS6110

KW - mycobacterium-tuberculosis complex

KW - nucleotide polymorphisms

KW - clinical isolate

KW - immune-response

KW - virulence

KW - genomes

KW - infection

KW - macrophages

KW - mutagenesis

KW - organisms

U2 - 10.1016/j.tube.2005.08.019

DO - 10.1016/j.tube.2005.08.019

M3 - Article

SN - 1472-9792

VL - 86

SP - 357

EP - 362

JO - Tuberculosis

JF - Tuberculosis

IS - 5

ER -

The genetic portrait of an outbreak strain

Abstract

Keywords

UN SDGs

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