The genetic prehistory of the New World Arctic

Maanasa Raghavan, Michael DeGiorgio, Anders Albrechtsen, Ida Moltke, Pontus Skoglund, Thorfinn S. Korneliussen, Bjarne Grønnow, Martin Appelt, Hans Christian Gulløv, T. Max Friesen, William Fitzhugh, Helena Malmström, Simon Rasmussen, Jesper Olsen, Linea Melchior, Benjamin T. Fuller, Simon M. Fahrni, Thomas Stafford Jr., Vaughan Grimes, M. A. Priscilla RenoufJerome Cybulski, Niels Lynnerup, Marta Mirazon Lahr, Kate Britton, Rick Knecht, Jette Arneborg, Mait Metspalu, Omar E. Cornejo, Anna-Sapfo Malaspinas, Yong Wang, Morten Rasmussen, Vibha Raghavan, Thomas V. O. Hansen, Elza Khusnutdinova, Tracey Pierre, Kirill Dneprovsky, Claus Andreasen, Hans Lange, M. Geoffrey Hayes, Joan Coltrain, Victor A. Spitsyn, Anders Götherström, Ludovic Orlando, Toomas Kivisild, Richard Villems, Michael H. Crawford, Finn C. Nielsen, Jørgen Dissing, Jan Heinemeier, Morten Meldgaard, Carlos Bustamante, Dennis H. O’Rourke, Mattias Jakobsson, M. Thomas P. Gilbert, Rasmus Nielsen, Eske Willerslev

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

The New World Arctic, the last region of the Americas to be populated by humans, has a relatively well-researched archaeology, but an understanding of its genetic history is lacking. We present genome-wide sequence data from ancient and present-day humans from Greenland, Arctic Canada, Alaska, Aleutian Islands, and Siberia. We show that Paleo-Eskimos (~3000 BCE to 1300 CE) represent a migration pulse into the Americas independent of both Native American and Inuit expansions. Furthermore, the genetic continuity characterizing the Paleo-Eskimo period was interrupted by the arrival of a new population, representing the ancestors of present-day Inuit, with evidence of past gene flow between these lineages. Despite periodic abandonment of major Arctic regions, a single Paleo-Eskimo metapopulation likely survived in near-isolation for more than 4000 years, only to vanish around 700 years ago.
Original languageEnglish
Pages (from-to)1020-1029
Number of pages10
JournalScience
Volume345
Issue number6200
DOIs
Publication statusPublished - 29 Aug 2014

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    Raghavan, M., DeGiorgio, M., Albrechtsen, A., Moltke, I., Skoglund, P., Korneliussen, T. S., Grønnow, B., Appelt, M., Gulløv, H. C., Friesen, T. M., Fitzhugh, W., Malmström, H., Rasmussen, S., Olsen, J., Melchior, L., Fuller, B. T., Fahrni, S. M., Stafford Jr., T., Grimes, V., ... Willerslev, E. (2014). The genetic prehistory of the New World Arctic. Science, 345(6200), 1020-1029. https://doi.org/10.1126/science.1255832