The health-related quality of life of people with peripheral arterial disease in the general population: Edinburgh Artery Study

J. C. Dumville, Amanda Jane Lee, F. B. Smith, F. G. R. Fowkes

Research output: Contribution to journalArticle

Abstract

Background: Previous studies investigating the health-related quality of life of those with peripheral arterial disease have focused on patients recruited from hospital clinics. The health related quality of life of people with peripheral arterial disease in the general population is unknown.

Aims. We aimed to determine the health-related quality of life of people with intermittent claudication and asymptomatic peripheral arterial disease in the general population and to compare it with those with angina and those with no peripheral arterial disease or angina.

Design of study: Analysis of cross-sectional data from the 12 year follow-up of a population-based cohort.

Setting: Edinburgh, Scotland.

Method: Data from the Edinburgh Artery Study cohort:5 12-year follow-up was analysed Participants' peripheral arterial disease status was measured using the World Health Organisation intermittent claudication questionnaire and the ankle brachial pressure index Self-assessed health-related quality of life data was collected using the SF-36 generic questionnaire. Health related quality of life scores were calculated and their associations with peripheral arterial disease status groups were tested Results. Subjects with intermittent claudication had significantly worse median health-related quality of life scores than patients without claudication in all domains except social functioning and mental health. Patients with claudication had a significantly lower physical component summary score than those without claudication (Pless than or equal to0.001). This association remained after adjustment for age, sex, social class, body mass index, smoking, and angina. Those with angina and claudication had significantly worse physical component summary scores than those with no peripheral arterial disease or angina (Pless than or equal to0.001). No significant difference was found in health-related quality of life scores between those with asymptomatic peripheral arterial disease and those with no peripheral arterial disease even after multiple adjustment for confounding factors.

Conclusion: People with intermittent claudication in the community had impaired health-related quality of life related to reduced physical health, but asymptomatic peripheral arterial disease did not significantly affect health-related quality of life.

Original languageEnglish
Pages (from-to)826-831
Number of pages5
JournalThe British Journal of General Practice
Volume54
Publication statusPublished - 2004

Keywords

  • angina pectoris
  • intermittent claudication
  • peripheral vascular disease
  • quality of life
  • INTERMITTENT CLAUDICATION
  • GENERAL-POPULATION
  • VASCULAR-DISEASE
  • QUESTIONNAIRE
  • UK

Cite this

The health-related quality of life of people with peripheral arterial disease in the general population: Edinburgh Artery Study. / Dumville, J. C.; Lee, Amanda Jane; Smith, F. B.; Fowkes, F. G. R.

In: The British Journal of General Practice, Vol. 54, 2004, p. 826-831.

Research output: Contribution to journalArticle

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abstract = "Background: Previous studies investigating the health-related quality of life of those with peripheral arterial disease have focused on patients recruited from hospital clinics. The health related quality of life of people with peripheral arterial disease in the general population is unknown.Aims. We aimed to determine the health-related quality of life of people with intermittent claudication and asymptomatic peripheral arterial disease in the general population and to compare it with those with angina and those with no peripheral arterial disease or angina.Design of study: Analysis of cross-sectional data from the 12 year follow-up of a population-based cohort.Setting: Edinburgh, Scotland.Method: Data from the Edinburgh Artery Study cohort:5 12-year follow-up was analysed Participants' peripheral arterial disease status was measured using the World Health Organisation intermittent claudication questionnaire and the ankle brachial pressure index Self-assessed health-related quality of life data was collected using the SF-36 generic questionnaire. Health related quality of life scores were calculated and their associations with peripheral arterial disease status groups were tested Results. Subjects with intermittent claudication had significantly worse median health-related quality of life scores than patients without claudication in all domains except social functioning and mental health. Patients with claudication had a significantly lower physical component summary score than those without claudication (Pless than or equal to0.001). This association remained after adjustment for age, sex, social class, body mass index, smoking, and angina. Those with angina and claudication had significantly worse physical component summary scores than those with no peripheral arterial disease or angina (Pless than or equal to0.001). No significant difference was found in health-related quality of life scores between those with asymptomatic peripheral arterial disease and those with no peripheral arterial disease even after multiple adjustment for confounding factors.Conclusion: People with intermittent claudication in the community had impaired health-related quality of life related to reduced physical health, but asymptomatic peripheral arterial disease did not significantly affect health-related quality of life.",
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T1 - The health-related quality of life of people with peripheral arterial disease in the general population: Edinburgh Artery Study

AU - Dumville, J. C.

AU - Lee, Amanda Jane

AU - Smith, F. B.

AU - Fowkes, F. G. R.

PY - 2004

Y1 - 2004

N2 - Background: Previous studies investigating the health-related quality of life of those with peripheral arterial disease have focused on patients recruited from hospital clinics. The health related quality of life of people with peripheral arterial disease in the general population is unknown.Aims. We aimed to determine the health-related quality of life of people with intermittent claudication and asymptomatic peripheral arterial disease in the general population and to compare it with those with angina and those with no peripheral arterial disease or angina.Design of study: Analysis of cross-sectional data from the 12 year follow-up of a population-based cohort.Setting: Edinburgh, Scotland.Method: Data from the Edinburgh Artery Study cohort:5 12-year follow-up was analysed Participants' peripheral arterial disease status was measured using the World Health Organisation intermittent claudication questionnaire and the ankle brachial pressure index Self-assessed health-related quality of life data was collected using the SF-36 generic questionnaire. Health related quality of life scores were calculated and their associations with peripheral arterial disease status groups were tested Results. Subjects with intermittent claudication had significantly worse median health-related quality of life scores than patients without claudication in all domains except social functioning and mental health. Patients with claudication had a significantly lower physical component summary score than those without claudication (Pless than or equal to0.001). This association remained after adjustment for age, sex, social class, body mass index, smoking, and angina. Those with angina and claudication had significantly worse physical component summary scores than those with no peripheral arterial disease or angina (Pless than or equal to0.001). No significant difference was found in health-related quality of life scores between those with asymptomatic peripheral arterial disease and those with no peripheral arterial disease even after multiple adjustment for confounding factors.Conclusion: People with intermittent claudication in the community had impaired health-related quality of life related to reduced physical health, but asymptomatic peripheral arterial disease did not significantly affect health-related quality of life.

AB - Background: Previous studies investigating the health-related quality of life of those with peripheral arterial disease have focused on patients recruited from hospital clinics. The health related quality of life of people with peripheral arterial disease in the general population is unknown.Aims. We aimed to determine the health-related quality of life of people with intermittent claudication and asymptomatic peripheral arterial disease in the general population and to compare it with those with angina and those with no peripheral arterial disease or angina.Design of study: Analysis of cross-sectional data from the 12 year follow-up of a population-based cohort.Setting: Edinburgh, Scotland.Method: Data from the Edinburgh Artery Study cohort:5 12-year follow-up was analysed Participants' peripheral arterial disease status was measured using the World Health Organisation intermittent claudication questionnaire and the ankle brachial pressure index Self-assessed health-related quality of life data was collected using the SF-36 generic questionnaire. Health related quality of life scores were calculated and their associations with peripheral arterial disease status groups were tested Results. Subjects with intermittent claudication had significantly worse median health-related quality of life scores than patients without claudication in all domains except social functioning and mental health. Patients with claudication had a significantly lower physical component summary score than those without claudication (Pless than or equal to0.001). This association remained after adjustment for age, sex, social class, body mass index, smoking, and angina. Those with angina and claudication had significantly worse physical component summary scores than those with no peripheral arterial disease or angina (Pless than or equal to0.001). No significant difference was found in health-related quality of life scores between those with asymptomatic peripheral arterial disease and those with no peripheral arterial disease even after multiple adjustment for confounding factors.Conclusion: People with intermittent claudication in the community had impaired health-related quality of life related to reduced physical health, but asymptomatic peripheral arterial disease did not significantly affect health-related quality of life.

KW - angina pectoris

KW - intermittent claudication

KW - peripheral vascular disease

KW - quality of life

KW - INTERMITTENT CLAUDICATION

KW - GENERAL-POPULATION

KW - VASCULAR-DISEASE

KW - QUESTIONNAIRE

KW - UK

M3 - Article

VL - 54

SP - 826

EP - 831

JO - The British Journal of General Practice

JF - The British Journal of General Practice

SN - 0960-1643

ER -