The Hippo signal transduction network in skeletal and cardiac muscle

Henning Wackerhage, Dominic P Del Re, Robert N Judson, Marius Sudol, Junichi Sadoshima

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through phosphorylation of the transcriptional coactivators Yap and Taz, which bind to and activate Teads. Additionally, many other signal transduction proteins crosstalk to members of the Hippo pathway forming a Hippo signal transduction network. We discuss evidence that the Hippo signal transduction network plays important roles in myogenesis, regeneration, muscular dystrophy, and rhabdomyosarcoma in skeletal muscle, as well as in myogenesis, organ size control, and regeneration of the heart. Understanding the role of Hippo kinases in skeletal and heart muscle physiology could have important implications for translational research.

Original languageEnglish
Article numberre4
JournalScience Signaling
Volume7
Issue number337
DOIs
Publication statusPublished - 5 Aug 2014

Fingerprint

Signal transduction
Muscle
Signal Transduction
Myocardium
Skeletal Muscle
Muscle Development
Regeneration
Transcription Factors
Research
Nucleotide Motifs
Phosphotransferases
Translational Medical Research
Organ Size
Rhabdomyosarcoma
Muscular Dystrophies
Diptera
Protein Kinases
Phosphorylation
Fruit
Physiology

Keywords

  • Adaptor Proteins, Signal Transducing
  • Heart
  • Humans
  • Models, Molecular
  • Muscle Development
  • Muscle, Skeletal
  • Myocardium
  • Phosphoproteins
  • Phosphorylation
  • Protein-Serine-Threonine Kinases
  • Regeneration
  • Rhabdomyosarcoma
  • Signal Transduction
  • Transcription Factors

Cite this

Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014). The Hippo signal transduction network in skeletal and cardiac muscle. Science Signaling, 7(337), [re4]. https://doi.org/10.1126/scisignal.2005096

The Hippo signal transduction network in skeletal and cardiac muscle. / Wackerhage, Henning; Del Re, Dominic P; Judson, Robert N; Sudol, Marius; Sadoshima, Junichi.

In: Science Signaling, Vol. 7, No. 337, re4, 05.08.2014.

Research output: Contribution to journalArticle

Wackerhage, H, Del Re, DP, Judson, RN, Sudol, M & Sadoshima, J 2014, 'The Hippo signal transduction network in skeletal and cardiac muscle' Science Signaling, vol. 7, no. 337, re4. https://doi.org/10.1126/scisignal.2005096
Wackerhage H, Del Re DP, Judson RN, Sudol M, Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Science Signaling. 2014 Aug 5;7(337). re4. https://doi.org/10.1126/scisignal.2005096
Wackerhage, Henning ; Del Re, Dominic P ; Judson, Robert N ; Sudol, Marius ; Sadoshima, Junichi. / The Hippo signal transduction network in skeletal and cardiac muscle. In: Science Signaling. 2014 ; Vol. 7, No. 337.
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