The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

Sinan Khadhouri* (Corresponding Author), Kevin M. Gallagher, Kenneth MacKenzie, Taimur T. Shah, Chuanyu Gao, Sacha Moore, Eleanor Zimmermann, Eric Edison, Matthew Jefferies, Arjun K. Nambiar, Miles Mannas, Taeweon Lee , Giancarlo Marra , Beatrice Lillaz , Juan Gómez Rivas, Jonathan olivier, Mark Assmus , Taha Uçar, Francesco Claps, Matteo Boltri Tara Burnhope, Nkwam Nkwam, George Tanasescu, Nicholas Boxall, Alison Downey , Asim Lal, Marta Antón-Juanilla , Holly Clarke, David Lau, Kathryn Gillams , Matthew Crockett, Matthew E. Nielsen, Yemisi Takwoingi, Naomi Chuchu , John O'Rourke, Graeme MacLennan, John McGrath, Veeru Kasivisvanathan, The IDENTIFY Study Group

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer (UTUC) and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. This was an international multicentre prospective observational study. We included patients aged 16 and over, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex and smoking. We used a multivariable mixed effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals and countries. Of the 11,059 patients assessed for eligibility, 10,896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n=2257) was 28.2% (95% CI 22.3-34.1), bladder cancer (n=1951) 24.7% (19.1-30.2), UTUC (n=128) 1.14% (0.77-1.52), renal cancer (n=107) 1.05% (0.80-1.29) and prostate cancer (n=124) 1.75% (1.32-2.18). Odds ratios for patient risk markers in the model for all cancers were: Age 1.04 (95% CI 1.03-1.05) p
Original languageEnglish
Pages (from-to)440-450
Number of pages12
JournalBJU International
Volume128
Issue number4
Early online date8 Sep 2021
DOIs
Publication statusPublished - 1 Oct 2021

Keywords

  • haematuria
  • bladder cancer
  • upper tract urothelial cancer
  • renal cancer
  • cancer prevalence
  • urinary tract cancer
  • prostate cancer

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