The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study

Ami Munro; Collette Gillespie; Seonaidh Cotton; Camille Busby-Earle; Kim Kavanagh; Kate Cuschieri; Heather Cubie; Chris Robertson; Louise Smart; Kevin Pollock; Catherine Moore; Timothy Palmer; Margaret E Cruickshank

doi:10.1111/1471-0528.14563

The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study

Ami Munro, Collette Gillespie, Seonaidh Cotton, Camille Busby-Earle, Kim Kavanagh, Kate Cuschieri, Heather Cubie, Chris Robertson, Louise Smart, Kevin Pollock, Catherine Moore, Timothy Palmer, Margaret E Cruickshank

Research output: Contribution to journal › Article

6 Citations (Scopus)

11 Downloads (Pure)

Abstract

Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.

Design: A two-centre observational study including vaccinated and unvaccinated women.

Setting: Colposcopy clinics serving two health regions in Scotland, UK.

Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.

Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.

Original language	English
Pages (from-to)	1394-1401
Number of pages	8
Journal	BJOG-An International Journal of Obstetrics and Gynaecology
Volume	124
Issue number	9
Early online date	9 Mar 2017
DOIs	https://doi.org/10.1111/1471-0528.14563
Publication status	Published - Aug 2017

Fingerprint

Keywords

colposcopy
HPV genotyping
cervical screening
HPV vaccine
CIN
cervical intraepithelial neoplasia
human papillomavirus
human papillomavirus genotyping
human papillomavirus vaccine

ASJC Scopus subject areas

Medicine(all)

Cite this

Munro, A., Gillespie, C., Cotton, S., Busby-Earle, C., Kavanagh, K., Cuschieri, K., ... Cruickshank, M. E. (2017). The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study. BJOG-An International Journal of Obstetrics and Gynaecology, 124(9), 1394-1401. https://doi.org/10.1111/1471-0528.14563

The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme : a two centre observational study. / Munro, Ami; Gillespie, Collette; Cotton, Seonaidh; Busby-Earle, Camille; Kavanagh, Kim; Cuschieri, Kate; Cubie, Heather; Robertson, Chris; Smart, Louise; Pollock, Kevin; Moore, Catherine; Palmer, Timothy; Cruickshank, Margaret E.

In: BJOG-An International Journal of Obstetrics and Gynaecology, Vol. 124, No. 9, 08.2017, p. 1394-1401.

Research output: Contribution to journal › Article

Munro, A, Gillespie, C, Cotton, S, Busby-Earle, C, Kavanagh, K, Cuschieri, K, Cubie, H, Robertson, C, Smart, L, Pollock, K, Moore, C, Palmer, T & Cruickshank, ME 2017, 'The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study', BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1394-1401. https://doi.org/10.1111/1471-0528.14563

Munro, Ami ; Gillespie, Collette ; Cotton, Seonaidh ; Busby-Earle, Camille ; Kavanagh, Kim ; Cuschieri, Kate ; Cubie, Heather ; Robertson, Chris ; Smart, Louise ; Pollock, Kevin ; Moore, Catherine ; Palmer, Timothy ; Cruickshank, Margaret E. / The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme : a two centre observational study. In: BJOG-An International Journal of Obstetrics and Gynaecology. 2017 ; Vol. 124, No. 9. pp. 1394-1401.

@article{1eb8fbe8bfb645528bba6bbdd7849342,

title = "The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study",

abstract = "Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.Design: A two-centre observational study including vaccinated and unvaccinated women.Setting: Colposcopy clinics serving two health regions in Scotland, UK.Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.",

keywords = "colposcopy, HPV genotyping, cervical screening, HPV vaccine, CIN, cervical intraepithelial neoplasia, human papillomavirus, human papillomavirus genotyping, human papillomavirus vaccine",

author = "Ami Munro and Collette Gillespie and Seonaidh Cotton and Camille Busby-Earle and Kim Kavanagh and Kate Cuschieri and Heather Cubie and Chris Robertson and Louise Smart and Kevin Pollock and Catherine Moore and Timothy Palmer and Cruickshank, {Margaret E}",

note = "Acknowledgements& Funding We would like to offer our sincere thanks to all the women who participated in this study and to the staff at NHS sites who facilitated this study. This study was funded by a CSO Programme grant (CSO reference number CZH/4/528) and NHS Grampian endowment grants. AM was awarded a bursary from The Jean Shanks Foundation for her contribution to this study.",

year = "2017",

month = "8",

doi = "10.1111/1471-0528.14563",

language = "English",

volume = "124",

pages = "1394--1401",

journal = "BJOG-An International Journal of Obstetrics and Gynaecology",

issn = "1470-0328",

publisher = "John Wiley & Sons, Ltd (10.1111)",

number = "9",

}

TY - JOUR

T1 - The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme

T2 - a two centre observational study

AU - Munro, Ami

AU - Gillespie, Collette

AU - Cotton, Seonaidh

AU - Busby-Earle, Camille

AU - Kavanagh, Kim

AU - Cuschieri, Kate

AU - Cubie, Heather

AU - Robertson, Chris

AU - Smart, Louise

AU - Pollock, Kevin

AU - Moore, Catherine

AU - Palmer, Timothy

AU - Cruickshank, Margaret E

N1 - Acknowledgements& Funding We would like to offer our sincere thanks to all the women who participated in this study and to the staff at NHS sites who facilitated this study. This study was funded by a CSO Programme grant (CSO reference number CZH/4/528) and NHS Grampian endowment grants. AM was awarded a bursary from The Jean Shanks Foundation for her contribution to this study.

PY - 2017/8

Y1 - 2017/8

N2 - Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.Design: A two-centre observational study including vaccinated and unvaccinated women.Setting: Colposcopy clinics serving two health regions in Scotland, UK.Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.

AB - Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.Design: A two-centre observational study including vaccinated and unvaccinated women.Setting: Colposcopy clinics serving two health regions in Scotland, UK.Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.

KW - colposcopy

KW - HPV genotyping

KW - cervical screening

KW - HPV vaccine

KW - CIN

KW - cervical intraepithelial neoplasia

KW - human papillomavirus

KW - human papillomavirus genotyping

KW - human papillomavirus vaccine

U2 - 10.1111/1471-0528.14563

DO - 10.1111/1471-0528.14563

M3 - Article

VL - 124

SP - 1394

EP - 1401

JO - BJOG-An International Journal of Obstetrics and Gynaecology

JF - BJOG-An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 9

ER -

Access to Document

10.1111/1471-0528.14563Licence: Unspecified

Accepted Manuscript
This is the peer reviewed version of the following article: Munro A, Gillespie C, Cotton S, Busby-Earle C, Kavanagh K, Cuschieri K, Cubie H, Robertson C, Smart L, Pollock K, Moore C, Palmer T, Cruickshank ME. The impact of human papillomavirus (HPV) type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two-centre observational study. BJOG 2017; 124:1394–1401., which has been published in final form at DOI: 10.1111/1471-0528.14563. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 57.1 KBLicence: Unspecified
Figure 1 suppAccepted author manuscript, 57 KB
Figure 2Accepted author manuscript, 100 KBLicence: Unspecified
Tables 123Accepted author manuscript, 17.3 KB
Table 4Accepted author manuscript, 28.5 KB