Abstract
Design: A two-centre observational study including vaccinated and unvaccinated women.
Setting: Colposcopy clinics serving two health regions in Scotland, UK.
Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.
Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
| Original language | English |
|---|---|
| Pages (from-to) | 1394-1401 |
| Number of pages | 8 |
| Journal | BJOG-An International Journal of Obstetrics and Gynaecology |
| Volume | 124 |
| Issue number | 9 |
| Early online date | 9 Mar 2017 |
| DOIs | |
| Publication status | Published - Aug 2017 |
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Keywords
- colposcopy
- HPV genotyping
- cervical screening
- HPV vaccine
- CIN
- cervical intraepithelial neoplasia
- human papillomavirus
- human papillomavirus genotyping
- human papillomavirus vaccine
ASJC Scopus subject areas
- Medicine(all)
Cite this
The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme : a two centre observational study. / Munro, Ami; Gillespie, Collette; Cotton, Seonaidh; Busby-Earle, Camille; Kavanagh, Kim; Cuschieri, Kate; Cubie, Heather; Robertson, Chris; Smart, Louise; Pollock, Kevin; Moore, Catherine; Palmer, Timothy; Cruickshank, Margaret E.
In: BJOG-An International Journal of Obstetrics and Gynaecology, Vol. 124, No. 9, 08.2017, p. 1394-1401.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme
T2 - a two centre observational study
AU - Munro, Ami
AU - Gillespie, Collette
AU - Cotton, Seonaidh
AU - Busby-Earle, Camille
AU - Kavanagh, Kim
AU - Cuschieri, Kate
AU - Cubie, Heather
AU - Robertson, Chris
AU - Smart, Louise
AU - Pollock, Kevin
AU - Moore, Catherine
AU - Palmer, Timothy
AU - Cruickshank, Margaret E
N1 - Acknowledgements& Funding We would like to offer our sincere thanks to all the women who participated in this study and to the staff at NHS sites who facilitated this study. This study was funded by a CSO Programme grant (CSO reference number CZH/4/528) and NHS Grampian endowment grants. AM was awarded a bursary from The Jean Shanks Foundation for her contribution to this study.
PY - 2017/8
Y1 - 2017/8
N2 - Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.Design: A two-centre observational study including vaccinated and unvaccinated women.Setting: Colposcopy clinics serving two health regions in Scotland, UK.Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
AB - Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.Design: A two-centre observational study including vaccinated and unvaccinated women.Setting: Colposcopy clinics serving two health regions in Scotland, UK.Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
KW - colposcopy
KW - HPV genotyping
KW - cervical screening
KW - HPV vaccine
KW - CIN
KW - cervical intraepithelial neoplasia
KW - human papillomavirus
KW - human papillomavirus genotyping
KW - human papillomavirus vaccine
U2 - 10.1111/1471-0528.14563
DO - 10.1111/1471-0528.14563
M3 - Article
VL - 124
SP - 1394
EP - 1401
JO - BJOG-An International Journal of Obstetrics and Gynaecology
JF - BJOG-An International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 9
ER -