Abstract
Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.
Design: A two-centre observational study including vaccinated and unvaccinated women.
Setting: Colposcopy clinics serving two health regions in Scotland, UK.
Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.
Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
Design: A two-centre observational study including vaccinated and unvaccinated women.
Setting: Colposcopy clinics serving two health regions in Scotland, UK.
Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.
Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
Original language | English |
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Pages (from-to) | 1394-1401 |
Number of pages | 8 |
Journal | BJOG-An International Journal of Obstetrics and Gynaecology |
Volume | 124 |
Issue number | 9 |
Early online date | 9 Mar 2017 |
DOIs | |
Publication status | Published - Aug 2017 |
Keywords
- colposcopy
- HPV genotyping
- cervical screening
- HPV vaccine
- CIN
- cervical intraepithelial neoplasia
- human papillomavirus
- human papillomavirus genotyping
- human papillomavirus vaccine