Abstract
Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.
Design: A two-centre observational study including vaccinated and unvaccinated women.
Setting: Colposcopy clinics serving two health regions in Scotland, UK.
Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.
Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
Design: A two-centre observational study including vaccinated and unvaccinated women.
Setting: Colposcopy clinics serving two health regions in Scotland, UK.
Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.
Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
| Original language | English |
|---|---|
| Pages (from-to) | 1394-1401 |
| Number of pages | 8 |
| Journal | BJOG-An International Journal of Obstetrics and Gynaecology |
| Volume | 124 |
| Issue number | 9 |
| Early online date | 9 Mar 2017 |
| DOIs | |
| Publication status | Published - Aug 2017 |
Bibliographical note
Acknowledgements& FundingWe would like to offer our sincere thanks to all the women who participated in this study and to the staff at NHS sites who facilitated this study.
This study was funded by a CSO Programme grant (CSO reference number CZH/4/528) and NHS Grampian endowment grants. AM was awarded a bursary from The Jean Shanks Foundation for her contribution to this study.
Keywords
- colposcopy
- HPV genotyping
- cervical screening
- HPV vaccine
- CIN
- cervical intraepithelial neoplasia
- human papillomavirus
- human papillomavirus genotyping
- human papillomavirus vaccine
Access to Document
- Accepted Manuscript
This is the peer reviewed version of the following article: Munro A, Gillespie C, Cotton S, Busby-Earle C, Kavanagh K, Cuschieri K, Cubie H, Robertson C, Smart L, Pollock K, Moore C, Palmer T, Cruickshank ME. The impact of human papillomavirus (HPV) type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two-centre observational study. BJOG 2017; 124:1394–1401., which has been published in final form at DOI: 10.1111/1471-0528.14563. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.