The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study

Ami Munro, Collette Gillespie, Seonaidh Cotton, Camille Busby-Earle, Kim Kavanagh, Kate Cuschieri, Heather Cubie, Chris Robertson, Louise Smart, Kevin Pollock, Catherine Moore, Timothy Palmer, Margaret E Cruickshank

Research output: Contribution to journalArticle

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Abstract

Objective: To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy.

Design: A two-centre observational study including vaccinated and unvaccinated women.

Setting: Colposcopy clinics serving two health regions in Scotland, UK.

Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.

Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
Original languageEnglish
Pages (from-to)1394-1401
Number of pages8
JournalBJOG-An International Journal of Obstetrics and Gynaecology
Volume124
Issue number9
Early online date9 Mar 2017
DOIs
Publication statusPublished - Aug 2017

Keywords

  • colposcopy
  • HPV genotyping
  • cervical screening
  • HPV vaccine
  • CIN
  • cervical intraepithelial neoplasia
  • human papillomavirus
  • human papillomavirus genotyping
  • human papillomavirus vaccine

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