The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

Nishat Siddiqi*, Christopher J. Neil, Jagpal Baljit, Jemma Hudson, Michael P. Frenneaux, Dana K. Dawson

*Corresponding author for this work

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Abstract

Background
Infarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.

Methods
55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.
Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalJournal of Cardiovascular Magnetic Resonance
Volume17
Issue numberSupplement 1
DOIs
Publication statusPublished - 3 Feb 2015

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