The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

Nishat Siddiqi, Christopher J. Neil, Jagpal Baljit, Jemma Hudson, Michael P. Frenneaux, Dana K. Dawson

Research output: Contribution to journalAbstract

3 Downloads (Pure)

Abstract

Background
Infarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.

Methods
55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.
Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalJournal of Cardiovascular Magnetic Resonance
Volume17
Issue numberSupplement 1
DOIs
Publication statusPublished - 3 Feb 2015

Fingerprint

Myocardial Infarction
Cicatrix
Myocardium
ST Elevation Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

Cite this

The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR. / Siddiqi, Nishat; Neil, Christopher J.; Baljit, Jagpal; Hudson, Jemma; Frenneaux, Michael P.; Dawson, Dana K.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 17, No. Supplement 1, 03.02.2015, p. 149-150.

Research output: Contribution to journalAbstract

@article{27892be6a33d404881fd389af2a068c4,
title = "The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR",
abstract = "BackgroundInfarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.Methods55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.",
author = "Nishat Siddiqi and Neil, {Christopher J.} and Jagpal Baljit and Jemma Hudson and Frenneaux, {Michael P.} and Dawson, {Dana K.}",
note = "Funding This project was funded by a grant from the MRC(UK).",
year = "2015",
month = "2",
day = "3",
doi = "10.1186/1532-429X-17-S1-P149",
language = "English",
volume = "17",
pages = "149--150",
journal = "Journal of Cardiovascular Magnetic Resonance",
issn = "1097-6647",
publisher = "BioMed Central",
number = "Supplement 1",

}

TY - JOUR

T1 - The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

AU - Siddiqi, Nishat

AU - Neil, Christopher J.

AU - Baljit, Jagpal

AU - Hudson, Jemma

AU - Frenneaux, Michael P.

AU - Dawson, Dana K.

N1 - Funding This project was funded by a grant from the MRC(UK).

PY - 2015/2/3

Y1 - 2015/2/3

N2 - BackgroundInfarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.Methods55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.

AB - BackgroundInfarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.Methods55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.

UR - http://www.scopus.com/inward/record.url?scp=84928691294&partnerID=8YFLogxK

U2 - 10.1186/1532-429X-17-S1-P149

DO - 10.1186/1532-429X-17-S1-P149

M3 - Abstract

VL - 17

SP - 149

EP - 150

JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

SN - 1097-6647

IS - Supplement 1

ER -