The Importance of Dietary Polyamines in Cell Regeneration and Growth

S BARDOCZ, T J DUGUID, David Stanley Brown, George Grant, A PUSZTAI, A WHITE, A RALPH

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

The polyamines putrescine, spermidine and spermine are essential for cell renewal and, therefore, are needed to keep the body healthy. It was previously believed that polyamines are synthesized by every cell in the body when required. However, in the present paper evidence is provided to show that, as in the case of the essential amino acids, the diet can supply sufficient amounts of polyamines to support cell renewal and growth. Systematic analysis of different foods was carried out and from the data obtained, the average daily polyamine consumption of British adults was calculated to be in the range 35-500 mu mol/person per d. The major sources of putrescine were fruit, cheese and non-green vegetables. All foods contributed similar amounts of spermidine to the diet, although levels were generally higher in green vegetables. Meat was the richest source of spermine. However, only a part of the polyamines supplied by the diet is available for use by the body. Based on experiments with rats it was established that polyamines were readily taken up from the gut lumen, probably by passive diffusion, and were partly metabolized during the process of absorption. More than 80% of the putrescine was converted to other polyamines and non-polyamine metabolites, mostly to amino acids. The enzyme responsible for controlling the bioavailability of putrescine was diamine oxidase (EC 1.4.3.6). For spermidine and spermine, however, about 70-80% of the intragastrically intubated dose remained in the original form. Considering the limitations on bioavailability (metabolism and conversion), the amounts of polyamines supplied by the average daily diet in Britain should satisfy metabolic requirements.

Original languageEnglish
Pages (from-to)819-828
Number of pages10
JournalBritish Journal of Nutrition
Volume73
Issue number6
DOIs
Publication statusPublished - Jun 1995

Keywords

  • polyamines
  • bioavailability
  • cell regeneration
  • phaseolus-vulgaris lectin
  • rat small-intestine
  • protein-synthesis
  • chain initiation
  • spermidine
  • oxidase
  • phytohemagglutinin
  • metabolism
  • eukaryotes
  • invitro

Cite this

BARDOCZ, S., DUGUID, T. J., Brown, D. S., Grant, G., PUSZTAI, A., WHITE, A., & RALPH, A. (1995). The Importance of Dietary Polyamines in Cell Regeneration and Growth. British Journal of Nutrition, 73(6), 819-828. https://doi.org/10.1079/BJN19950087

The Importance of Dietary Polyamines in Cell Regeneration and Growth. / BARDOCZ, S ; DUGUID, T J ; Brown, David Stanley; Grant, George; PUSZTAI, A ; WHITE, A ; RALPH, A .

In: British Journal of Nutrition, Vol. 73, No. 6, 06.1995, p. 819-828.

Research output: Contribution to journalArticle

BARDOCZ, S, DUGUID, TJ, Brown, DS, Grant, G, PUSZTAI, A, WHITE, A & RALPH, A 1995, 'The Importance of Dietary Polyamines in Cell Regeneration and Growth', British Journal of Nutrition, vol. 73, no. 6, pp. 819-828. https://doi.org/10.1079/BJN19950087
BARDOCZ S, DUGUID TJ, Brown DS, Grant G, PUSZTAI A, WHITE A et al. The Importance of Dietary Polyamines in Cell Regeneration and Growth. British Journal of Nutrition. 1995 Jun;73(6):819-828. https://doi.org/10.1079/BJN19950087
BARDOCZ, S ; DUGUID, T J ; Brown, David Stanley ; Grant, George ; PUSZTAI, A ; WHITE, A ; RALPH, A . / The Importance of Dietary Polyamines in Cell Regeneration and Growth. In: British Journal of Nutrition. 1995 ; Vol. 73, No. 6. pp. 819-828.
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