The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi

Chantal Fernandes, Neil A. R. Gow, Teresa Gonçalves

Research output: Contribution to journalArticle

12 Citations (Scopus)
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Abstract

Chitin represents one of themost important components of the fungal cellwall. Themultiplicity of chitin synthase (Chs) enzymes found in filamentous fungi underlines the importance of chitin in these organisms. Among this group of fungal enzymes, two classes, V and VII, are armed with myosin motors, constituting the MMD-Chs (Myosin Motor Domain e Chitin synthases) that are
found in filamentous fungi and are absent in most yeast species. These enzymes play a critical role in promoting the synthesis of chitin at the hyphal tip, thus influencing fungal growth and the architecture of fungal infection structures. Other processes in which these enzymes are important are in osmo- and H2O2-tolerance, the ability to grow at 37 C and in conidiogenesis.
This review is focussed on the classification, structure and function of these enzymesdescribing the fundamental role of these enzymes in the ability of filamentous fungi to infect plants and their possible involvement in infections of animals. Moreover, data obtained with deletant mutants of this family of proteins indicates that they have potential as targets for novel antifungals.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalFungal Biology Reviews
Volume30
Issue number1
Early online date26 Apr 2016
DOIs
Publication statusPublished - Apr 2016

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Keywords

  • chitin synthase
  • class V
  • class VII
  • filamentous fungi
  • myosin-like domain

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