The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation

M Vickers, G Jackson, P Taylor

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

It is believed that most malignancies become more common with increasing age due to the requirement for several mutations to accumulate and subsequently interact. The age specific incidence of acute promyelocytic leukemia (APL) was investigated using population-based data from 77 million subject years of observation, yielding 149 consecutive cases. The incidence appears approximately constant with respect to age, an observation not previously reported with any other malignancy. These findings are most easily explained by there being only one rate limiting genetic event required to initiate the disease, although other, non-rate limiting mutations may also be necessary for disease development. It is also argued that this mutation is probably restricted to cells committed to differentiation, which may explain why APL is curable by chemotherapy.

Original languageEnglish
Pages (from-to)722-726
Number of pages5
JournalLeukemia
Volume14
Publication statusPublished - 2000

Keywords

  • acute promyelocytic leukemia
  • epidemiology
  • population genetics
  • translocation
  • PML-RAR-ALPHA
  • ACUTE MYELOID-LEUKEMIA
  • RETINOIC ACID
  • TRANSGENIC MICE
  • FUSION PROTEIN
  • CELL LINEAGE
  • DIFFERENTIATION
  • TRANSLOCATION
  • MULTISTAGE
  • CANCER

Cite this

The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation. / Vickers, M ; Jackson, G ; Taylor, P .

In: Leukemia, Vol. 14, 2000, p. 722-726.

Research output: Contribution to journalArticle

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AB - It is believed that most malignancies become more common with increasing age due to the requirement for several mutations to accumulate and subsequently interact. The age specific incidence of acute promyelocytic leukemia (APL) was investigated using population-based data from 77 million subject years of observation, yielding 149 consecutive cases. The incidence appears approximately constant with respect to age, an observation not previously reported with any other malignancy. These findings are most easily explained by there being only one rate limiting genetic event required to initiate the disease, although other, non-rate limiting mutations may also be necessary for disease development. It is also argued that this mutation is probably restricted to cells committed to differentiation, which may explain why APL is curable by chemotherapy.

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KW - TRANSGENIC MICE

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