THE INFLUENCE OF A LOW-BORON DIET AND BORON SUPPLEMENTATION ON BONE, MAJOR MINERAL AND SEX STEROID-METABOLISM IN POSTMENOPAUSAL WOMEN

J H BEATTIE, H S PEACE

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    An increase in dietary intake of B from 0.25 to 3.25 mg/d has been reported to increase plasma oestradiol and testosterone and decrease urinary Ca excretion in postmenopausal women. Consequently, it is suggested that the higher level of B intake could reduce bone loss associated with the menopause and cessation of ovarian function. The present study was designed to investigate the effect of a B supplement on bone mineral absorption and excretion, plasma sex steroid levels and urinary excretion of pyridinium crosslink markers of bone turnover in healthy postmenopausal volunteers. The women were accommodated in a metabolic unit, given a low-B diet (LBD; 0-33 mg/d) for 3 weeks and were asked to take a B supplement of 3 mg/d in addition to the LBD for a further 3 weeks. Changing B intake from 0.33 to 3.33 mg/d had no effect on minerals, steroids or crosslinks. However, the LBD appeared to induce hyperabsorption of Ca since positive Ca balances were found in combination with elevated urinary Ca excretion. This phenomenon may have inhibited or obscured any effect of B.

    Original languageEnglish
    Pages (from-to)871-884
    Number of pages14
    JournalBritish Journal of Nutrition
    Volume69
    Issue number3
    Publication statusPublished - May 1993

    Keywords

    • BORON
    • CALCIUM
    • BONE TURNOVER
    • ESTROGEN
    • RATS
    • VEGETARIAN
    • RESORPTION
    • EXCRETION
    • MAGNESIUM
    • DISEASES
    • MARKERS

    Cite this

    THE INFLUENCE OF A LOW-BORON DIET AND BORON SUPPLEMENTATION ON BONE, MAJOR MINERAL AND SEX STEROID-METABOLISM IN POSTMENOPAUSAL WOMEN. / BEATTIE, J H ; PEACE, H S .

    In: British Journal of Nutrition, Vol. 69, No. 3, 05.1993, p. 871-884.

    Research output: Contribution to journalArticle

    @article{2d3529faf9db44a7b5a2a023f4fd2318,
    title = "THE INFLUENCE OF A LOW-BORON DIET AND BORON SUPPLEMENTATION ON BONE, MAJOR MINERAL AND SEX STEROID-METABOLISM IN POSTMENOPAUSAL WOMEN",
    abstract = "An increase in dietary intake of B from 0.25 to 3.25 mg/d has been reported to increase plasma oestradiol and testosterone and decrease urinary Ca excretion in postmenopausal women. Consequently, it is suggested that the higher level of B intake could reduce bone loss associated with the menopause and cessation of ovarian function. The present study was designed to investigate the effect of a B supplement on bone mineral absorption and excretion, plasma sex steroid levels and urinary excretion of pyridinium crosslink markers of bone turnover in healthy postmenopausal volunteers. The women were accommodated in a metabolic unit, given a low-B diet (LBD; 0-33 mg/d) for 3 weeks and were asked to take a B supplement of 3 mg/d in addition to the LBD for a further 3 weeks. Changing B intake from 0.33 to 3.33 mg/d had no effect on minerals, steroids or crosslinks. However, the LBD appeared to induce hyperabsorption of Ca since positive Ca balances were found in combination with elevated urinary Ca excretion. This phenomenon may have inhibited or obscured any effect of B.",
    keywords = "BORON, CALCIUM, BONE TURNOVER, ESTROGEN, RATS, VEGETARIAN, RESORPTION, EXCRETION, MAGNESIUM, DISEASES, MARKERS",
    author = "BEATTIE, {J H} and PEACE, {H S}",
    year = "1993",
    month = "5",
    language = "English",
    volume = "69",
    pages = "871--884",
    journal = "British Journal of Nutrition",
    issn = "0007-1145",
    publisher = "Cambridge Univ. Press.",
    number = "3",

    }

    TY - JOUR

    T1 - THE INFLUENCE OF A LOW-BORON DIET AND BORON SUPPLEMENTATION ON BONE, MAJOR MINERAL AND SEX STEROID-METABOLISM IN POSTMENOPAUSAL WOMEN

    AU - BEATTIE, J H

    AU - PEACE, H S

    PY - 1993/5

    Y1 - 1993/5

    N2 - An increase in dietary intake of B from 0.25 to 3.25 mg/d has been reported to increase plasma oestradiol and testosterone and decrease urinary Ca excretion in postmenopausal women. Consequently, it is suggested that the higher level of B intake could reduce bone loss associated with the menopause and cessation of ovarian function. The present study was designed to investigate the effect of a B supplement on bone mineral absorption and excretion, plasma sex steroid levels and urinary excretion of pyridinium crosslink markers of bone turnover in healthy postmenopausal volunteers. The women were accommodated in a metabolic unit, given a low-B diet (LBD; 0-33 mg/d) for 3 weeks and were asked to take a B supplement of 3 mg/d in addition to the LBD for a further 3 weeks. Changing B intake from 0.33 to 3.33 mg/d had no effect on minerals, steroids or crosslinks. However, the LBD appeared to induce hyperabsorption of Ca since positive Ca balances were found in combination with elevated urinary Ca excretion. This phenomenon may have inhibited or obscured any effect of B.

    AB - An increase in dietary intake of B from 0.25 to 3.25 mg/d has been reported to increase plasma oestradiol and testosterone and decrease urinary Ca excretion in postmenopausal women. Consequently, it is suggested that the higher level of B intake could reduce bone loss associated with the menopause and cessation of ovarian function. The present study was designed to investigate the effect of a B supplement on bone mineral absorption and excretion, plasma sex steroid levels and urinary excretion of pyridinium crosslink markers of bone turnover in healthy postmenopausal volunteers. The women were accommodated in a metabolic unit, given a low-B diet (LBD; 0-33 mg/d) for 3 weeks and were asked to take a B supplement of 3 mg/d in addition to the LBD for a further 3 weeks. Changing B intake from 0.33 to 3.33 mg/d had no effect on minerals, steroids or crosslinks. However, the LBD appeared to induce hyperabsorption of Ca since positive Ca balances were found in combination with elevated urinary Ca excretion. This phenomenon may have inhibited or obscured any effect of B.

    KW - BORON

    KW - CALCIUM

    KW - BONE TURNOVER

    KW - ESTROGEN

    KW - RATS

    KW - VEGETARIAN

    KW - RESORPTION

    KW - EXCRETION

    KW - MAGNESIUM

    KW - DISEASES

    KW - MARKERS

    M3 - Article

    VL - 69

    SP - 871

    EP - 884

    JO - British Journal of Nutrition

    JF - British Journal of Nutrition

    SN - 0007-1145

    IS - 3

    ER -