The influence of the 4 allele of the apolipoprotein E gene on childhood IQ, non-verbal reasoning in old age, and lifetime cognitive change

I. J. Deary, Lawrence Jeffrey Whalley, David Malcolm St Clair, Gerome Daniel Breen, S. Leaper, H.a. Lemmon, C. Hayward, J. M. Starr

Research output: Contribution to journalArticlepeer-review


We examined the influence of APOE epsilon4 allele status on three cognitive outcomes in the same sample of 173 people: (i) IQ (Moray House Test) at age 11 years, (ii) IQ (Raven's Standard Progressive Matrices) at age 77 years, and (iii) change in IQ between age 11 and 77. All participants took part in the Scottish Mental Survey of 1932 and were, followed-up in 1997-1998. There was no significant main effect of gene status on IQ in youth or old age, nor in cognitive change across the lifespan. Sex had no effect on the three cognitive outcome variables and did not interact with APOE epsilon4 allele status. (C) 2003 Elsevier Science Inc. All rights reserved.

Original languageEnglish
Pages (from-to)85-92
Number of pages7
Issue number1
Early online date14 May 2002
Publication statusPublished - Jan 2003


  • APOE
  • intelligence
  • ageing
  • genetics
  • dementia
  • cognition
  • mental-ability
  • Alzheimers-Disease
  • E polymorphism
  • risk-factors
  • association
  • decline
  • health
  • twins

Cite this