The influence  of the 4 allele of the apolipoprotein E gene on childhood IQ, non-verbal reasoning in old age, and lifetime cognitive change

I. J. Deary; Lawrence Jeffrey Whalley; David Malcolm St Clair; Gerome Daniel Breen; S. Leaper; H.a. Lemmon; C. Hayward; J. M. Starr

doi:10.1016/S0160-2896(02)00114-9

The influence of the 4 allele of the apolipoprotein E gene on childhood IQ, non-verbal reasoning in old age, and lifetime cognitive change

I. J. Deary, Lawrence Jeffrey Whalley, David Malcolm St Clair, Gerome Daniel Breen, S. Leaper, H.a. Lemmon, C. Hayward, J. M. Starr

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the influence of APOE epsilon4 allele status on three cognitive outcomes in the same sample of 173 people: (i) IQ (Moray House Test) at age 11 years, (ii) IQ (Raven's Standard Progressive Matrices) at age 77 years, and (iii) change in IQ between age 11 and 77. All participants took part in the Scottish Mental Survey of 1932 and were, followed-up in 1997-1998. There was no significant main effect of gene status on IQ in youth or old age, nor in cognitive change across the lifespan. Sex had no effect on the three cognitive outcome variables and did not interact with APOE epsilon4 allele status. (C) 2003 Elsevier Science Inc. All rights reserved.

Original language	English
Pages (from-to)	85-92
Number of pages	7
Journal	Intelligence
Volume	31
Issue number	1
Early online date	14 May 2002
DOIs	https://doi.org/10.1016/S0160-2896(02)00114-9
Publication status	Published - Jan 2003

Keywords

APOE
intelligence
ageing
genetics
dementia
cognition
mental-ability
Alzheimers-Disease
E polymorphism
risk-factors
association
decline
health
twins

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10.1016/S0160-2896(02)00114-9

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title = "The influence of the 4 allele of the apolipoprotein E gene on childhood IQ, non-verbal reasoning in old age, and lifetime cognitive change",

abstract = "We examined the influence of APOE epsilon4 allele status on three cognitive outcomes in the same sample of 173 people: (i) IQ (Moray House Test) at age 11 years, (ii) IQ (Raven's Standard Progressive Matrices) at age 77 years, and (iii) change in IQ between age 11 and 77. All participants took part in the Scottish Mental Survey of 1932 and were, followed-up in 1997-1998. There was no significant main effect of gene status on IQ in youth or old age, nor in cognitive change across the lifespan. Sex had no effect on the three cognitive outcome variables and did not interact with APOE epsilon4 allele status. (C) 2003 Elsevier Science Inc. All rights reserved.",

keywords = "APOE, intelligence, ageing, genetics, dementia, cognition, mental-ability, Alzheimers-Disease, E polymorphism, risk-factors, association, decline, health, twins",

author = "Deary, {I. J.} and Whalley, {Lawrence Jeffrey} and {St Clair}, {David Malcolm} and Breen, {Gerome Daniel} and S. Leaper and H.a. Lemmon and C. Hayward and Starr, {J. M.}",

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AU - Deary, I. J.

AU - Whalley, Lawrence Jeffrey

AU - St Clair, David Malcolm

AU - Breen, Gerome Daniel

AU - Leaper, S.

AU - Lemmon, H.a.

AU - Hayward, C.

AU - Starr, J. M.

PY - 2003/1

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AB - We examined the influence of APOE epsilon4 allele status on three cognitive outcomes in the same sample of 173 people: (i) IQ (Moray House Test) at age 11 years, (ii) IQ (Raven's Standard Progressive Matrices) at age 77 years, and (iii) change in IQ between age 11 and 77. All participants took part in the Scottish Mental Survey of 1932 and were, followed-up in 1997-1998. There was no significant main effect of gene status on IQ in youth or old age, nor in cognitive change across the lifespan. Sex had no effect on the three cognitive outcome variables and did not interact with APOE epsilon4 allele status. (C) 2003 Elsevier Science Inc. All rights reserved.

KW - APOE

KW - intelligence

KW - ageing

KW - genetics

KW - dementia

KW - cognition

KW - mental-ability

KW - Alzheimers-Disease

KW - E polymorphism

KW - risk-factors

KW - association

KW - decline

KW - health

KW - twins

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DO - 10.1016/S0160-2896(02)00114-9

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SP - 85

EP - 92

JO - Intelligence

JF - Intelligence

SN - 0160-2896

IS - 1

ER -

The influence of the 4 allele of the apolipoprotein E gene on childhood IQ, non-verbal reasoning in old age, and lifetime cognitive change

Abstract

Keywords

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