The inhibition of TNF-α-induced NF-κB activation by marine natural products

Florence Folmer; Marcel Jaspars; Godofredo Solano; Silvia Cristofanon; Estelle Henry; Jioji Tabudravu; Katie Black; David H. Green; Frithjof C. Kuepper; William Aalbersberg; Klaus Feussner; Mario Dicato; Marc Diederich

doi:10.1016/j.bcp.2009.05.009

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Florence Folmer, Marcel Jaspars, Godofredo Solano, Silvia Cristofanon, Estelle Henry, Jioji Tabudravu, Katie Black, David H. Green, Frithjof C. Kuepper, William Aalbersberg, Klaus Feussner, Mario Dicato, Marc Diederich

Chemistry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins.

Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	592-606
Number of pages	15
Journal	Biochemical Pharmacology
Volume	78
Issue number	6
Early online date	13 May 2009
DOIs	https://doi.org/10.1016/j.bcp.2009.05.009
Publication status	Published - 15 Sept 2009

Keywords

NF-kappa B
marine natural product
anti-cancer drug discovery
tumor-necrosis-factor
transcription factor
fatty-acid
drug development
cancer-therapy
comanthus-parvicirrus
targeted modulators
chlorococcum sp
DNA-binding
green-alga

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bcp.2009.05.009

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title = "The inhibition of TNF-α-induced NF-κB activation by marine natural products",

abstract = "The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins.Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.",

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author = "Florence Folmer and Marcel Jaspars and Godofredo Solano and Silvia Cristofanon and Estelle Henry and Jioji Tabudravu and Katie Black and Green, {David H.} and Kuepper, {Frithjof C.} and William Aalbersberg and Klaus Feussner and Mario Dicato and Marc Diederich",

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AU - Jaspars, Marcel

AU - Solano, Godofredo

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AU - Henry, Estelle

AU - Tabudravu, Jioji

AU - Black, Katie

AU - Green, David H.

AU - Kuepper, Frithjof C.

AU - Aalbersberg, William

AU - Feussner, Klaus

AU - Dicato, Mario

AU - Diederich, Marc

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AB - The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins.Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.

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The inhibition of TNF-α-induced NF-κB activation by marine natural products

Abstract

Keywords

UN SDGs

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