The innate and adaptive immune system of fish

C. J. Secombes*, T. Wang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

105 Citations (Scopus)


This chapter describes what is known about the main components and responses of the innate and adaptive immune system of fish. The chapter first reviews the organs, cells and molecules of the immune system known in a few economically important or model fish species. Molecular evidence suggests a similar immune system exists throughout the jawed vertebrates yet marked differences are also apparent. The innate parameters are at the forefront of fish immune defence and are a crucial factor in disease resistance. The adaptive response of fish is commonly delayed but is essential for long lasting immunity and a key factor in successful vaccination.

Original languageEnglish
Title of host publicationInfectious Disease in Aquaculture
Subtitle of host publicationPrevention and Control
PublisherElsevier Inc.
Number of pages66
ISBN (Print)9780857090164
Publication statusPublished - 1 Apr 2012


  • Adaptive immune responses
  • Fish immune organs
  • Immune regulation
  • Innate immune responses
  • Pattern recognition receptors (PRR)


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