The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Stefan Frantz; Ines Falcao-Pires; Jean-Luc Balligand; Johann Bauersachs; Dirk Brutsaert; Michele Ciccarelli; Dana Dawson; Leon J de Windt; Mauro Giacca; Nazha Hamdani; Denise Hilfiker-Kleiner; Emilio Hirsch; Adelino Leite-Moreira; Manuel Mayr; Thomas Thum; Carlo G Tocchetti; Jolanda van der Velden; Gilda Varricchi; Stephane Heymans

doi:10.1002/ejhf.1138

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Stefan Frantz, Ines Falcao-Pires, Jean-Luc Balligand, Johann Bauersachs, Dirk Brutsaert, Michele Ciccarelli, Dana Dawson, Leon J de Windt, Mauro Giacca, Nazha Hamdani, Denise Hilfiker-Kleiner, Emilio Hirsch, Adelino Leite-Moreira, Manuel Mayr, Thomas Thum, Carlo G Tocchetti, Jolanda van der Velden, Gilda Varricchi, Stephane Heymans

Applied Medicine

Research output: Contribution to journal › Review article › peer-review

115 Citations (Scopus)

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Abstract

Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies.

Original language	English
Pages (from-to)	445-459
Number of pages	15
Journal	European Journal of Heart Failure
Volume	20
Issue number	3
Early online date	15 Jan 2018
DOIs	https://doi.org/10.1002/ejhf.1138
Publication status	Published - Mar 2018

Bibliographical note

Funded by
Regione Campania CISI-Lab
European Union Commission's Seventh Framework . Grant Number: 305507, 602904
FP7-Health-2013-Innovations-1. Grant Number: 602156
FWO Flanders, Belgium. Grant Number: FWO G080014 N
European Union Horizon2020. Grant Number: UE LSHM-CT-05-018833, FNRS PDR T.0144.13
Bundesministerium für Bildung und Forschung. Grant Number: BMBF01 EO1004
Deutsche Forschungsgemeinschaft. Grant Number: SFB688 TP A10

Keywords

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ejhf.1138Licence: CC BY-NC

The innate immune system in chronic cardiomyopathy
© 2018 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. https://creativecommons.org/licenses/by-nc/4.0/
Final published version, 3.71 MBLicence: CC BY-NC

Cite this

Frantz, S., Falcao-Pires, I., Balligand, J.-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G., & Heymans, S. (2018). The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. European Journal of Heart Failure, 20(3), 445-459. https://doi.org/10.1002/ejhf.1138

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. / Frantz, Stefan; Falcao-Pires, Ines; Balligand, Jean-Luc et al.
In: European Journal of Heart Failure, Vol. 20, No. 3, 03.2018, p. 445-459.

Research output: Contribution to journal › Review article › peer-review

Frantz, S, Falcao-Pires, I, Balligand, J-L, Bauersachs, J, Brutsaert, D, Ciccarelli, M, Dawson, D, de Windt, LJ, Giacca, M, Hamdani, N, Hilfiker-Kleiner, D, Hirsch, E, Leite-Moreira, A, Mayr, M, Thum, T, Tocchetti, CG, van der Velden, J, Varricchi, G & Heymans, S 2018, 'The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC', European Journal of Heart Failure, vol. 20, no. 3, pp. 445-459. https://doi.org/10.1002/ejhf.1138

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abstract = "Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies.",

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AU - Brutsaert, Dirk

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AU - de Windt, Leon J

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The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

Abstract

Bibliographical note

Keywords

UN SDGs

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