The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Kelly S. Swanson* (Corresponding Author), Glenn R Gibson, Robert Hutkins, Raylene A. Reimer, Gregor Reid, Kristin Verbeke, Karen P. Scott, Hannah D. Holscher, Meghan B. Azad, Nathalie M. Delzenne, Mary Ellen Sanders

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Gut microbiota can be manipulated to benefit host health, including the use of probiotics, prebiotics and synbiotics. This Consensus Statement outlines the definition and scope of the term 'synbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in May 2019.

In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

Original languageEnglish
Number of pages17
JournalNature Reviews Gastroenterology & Hepatology
Early online date21 Aug 2020
DOIs
Publication statusE-pub ahead of print - 21 Aug 2020

Keywords

  • RANDOMIZED CLINICAL-TRIAL
  • IRRITABLE-BOWEL-SYNDROME
  • FATTY LIVER-DISEASE
  • DOUBLE-BLIND
  • GUT MICROBIOTA
  • ATOPIC-DERMATITIS
  • OXIDATIVE STRESS
  • POSTOPERATIVE COMPLICATIONS
  • INFECTIOUS COMPLICATIONS
  • BIFIDOBACTERIUM-LONGUM

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