The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Kelly S. Swanson; Glenn R Gibson; Robert Hutkins; Raylene A. Reimer; Gregor Reid; Kristin Verbeke; Karen P. Scott; Hannah D.  Holscher; Meghan B.  Azad; Nathalie M. Delzenne; Mary Ellen Sanders

doi:10.1038/s41575-020-0344-2

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Kelly S. Swanson^* (Corresponding Author), Glenn R Gibson, Robert Hutkins, Raylene A. Reimer, Gregor Reid, Kristin Verbeke, Karen P. Scott, Hannah D. Holscher, Meghan B. Azad, Nathalie M. Delzenne, Mary Ellen Sanders

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

623 Citations (Scopus)

3 Downloads (Pure)

Abstract

Gut microbiota can be manipulated to benefit host health, including the use of probiotics, prebiotics and synbiotics. This Consensus Statement outlines the definition and scope of the term 'synbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in May 2019.

In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

Original language	English
Pages (from-to)	687-701
Number of pages	17
Journal	Nature Reviews Gastroenterology & Hepatology
Volume	17
Issue number	11
Early online date	21 Aug 2020
DOIs	https://doi.org/10.1038/s41575-020-0344-2
Publication status	Published - Nov 2020

Bibliographical note

Acknowledgements:
This panel was supported by the International Scientific Association for Probiotics and Prebiotics (ISAPP), a not-for-profit organization dedicated to advancing the science of probiotics and prebiotics. ISAPP’s activities are determined by its volunteer board of directors, comprising academic scientists. Through its Industry Advisory Committee, ISAPP incorporates industry scientists in its activities and raises funds. ISAPP strives to be an objective, science-based voice for the probiotic and prebiotic fields. The content of this paper was reviewed and approved by the ISAPP board of directors. The Rowett Institute (K.P.S.) receives financial support from the Scottish Government (RESAS).

Keywords

RANDOMIZED CLINICAL-TRIAL
IRRITABLE-BOWEL-SYNDROME
FATTY LIVER-DISEASE
DOUBLE-BLIND
GUT MICROBIOTA
ATOPIC-DERMATITIS
OXIDATIVE STRESS
POSTOPERATIVE COMPLICATIONS
INFECTIOUS COMPLICATIONS
BIFIDOBACTERIUM-LONGUM

Access to Document

10.1038/s41575-020-0344-2Licence: CC BY

Swanson_et-al_international-scientific_nature_reviews_gastroenterology_hepatology_vor
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 1.6 MBLicence: CC BY

Cite this

Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., & Sanders, M. E. (2020). The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nature Reviews Gastroenterology & Hepatology, 17(11), 687-701. https://doi.org/10.1038/s41575-020-0344-2

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. / Swanson, Kelly S. (Corresponding Author); Gibson, Glenn R; Hutkins, Robert et al.
In: Nature Reviews Gastroenterology & Hepatology, Vol. 17, No. 11, 11.2020, p. 687-701.

Research output: Contribution to journal › Article › peer-review

Swanson, KS, Gibson, GR, Hutkins, R, Reimer, RA, Reid, G, Verbeke, K, Scott, KP, Holscher, HD, Azad, MB, Delzenne, NM & Sanders, ME 2020, 'The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics', Nature Reviews Gastroenterology & Hepatology, vol. 17, no. 11, pp. 687-701. https://doi.org/10.1038/s41575-020-0344-2

@article{ed8250d3ef404d7da4013699fcedeab6,

title = "The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics",

abstract = "Gut microbiota can be manipulated to benefit host health, including the use of probiotics, prebiotics and synbiotics. This Consensus Statement outlines the definition and scope of the term 'synbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in May 2019.In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to {"}a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host{"}. The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.",

keywords = "RANDOMIZED CLINICAL-TRIAL, IRRITABLE-BOWEL-SYNDROME, FATTY LIVER-DISEASE, DOUBLE-BLIND, GUT MICROBIOTA, ATOPIC-DERMATITIS, OXIDATIVE STRESS, POSTOPERATIVE COMPLICATIONS, INFECTIOUS COMPLICATIONS, BIFIDOBACTERIUM-LONGUM",

author = "Swanson, {Kelly S.} and Gibson, {Glenn R} and Robert Hutkins and Reimer, {Raylene A.} and Gregor Reid and Kristin Verbeke and Scott, {Karen P.} and Holscher, {Hannah D.} and Azad, {Meghan B.} and Delzenne, {Nathalie M.} and Sanders, {Mary Ellen}",

note = "Acknowledgements: This panel was supported by the International Scientific Association for Probiotics and Prebiotics (ISAPP), a not-for-profit organization dedicated to advancing the science of probiotics and prebiotics. ISAPP{\textquoteright}s activities are determined by its volunteer board of directors, comprising academic scientists. Through its Industry Advisory Committee, ISAPP incorporates industry scientists in its activities and raises funds. ISAPP strives to be an objective, science-based voice for the probiotic and prebiotic fields. The content of this paper was reviewed and approved by the ISAPP board of directors. The Rowett Institute (K.P.S.) receives financial support from the Scottish Government (RESAS).",

year = "2020",

month = nov,

doi = "10.1038/s41575-020-0344-2",

language = "English",

volume = "17",

pages = "687--701",

journal = "Nature Reviews Gastroenterology & Hepatology",

issn = "1759-5045",

number = "11",

}

TY - JOUR

T1 - The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

AU - Swanson, Kelly S.

AU - Gibson, Glenn R

AU - Hutkins, Robert

AU - Reimer, Raylene A.

AU - Reid, Gregor

AU - Verbeke, Kristin

AU - Scott, Karen P.

AU - Holscher, Hannah D.

AU - Azad, Meghan B.

AU - Delzenne, Nathalie M.

AU - Sanders, Mary Ellen

N1 - Acknowledgements: This panel was supported by the International Scientific Association for Probiotics and Prebiotics (ISAPP), a not-for-profit organization dedicated to advancing the science of probiotics and prebiotics. ISAPP’s activities are determined by its volunteer board of directors, comprising academic scientists. Through its Industry Advisory Committee, ISAPP incorporates industry scientists in its activities and raises funds. ISAPP strives to be an objective, science-based voice for the probiotic and prebiotic fields. The content of this paper was reviewed and approved by the ISAPP board of directors. The Rowett Institute (K.P.S.) receives financial support from the Scottish Government (RESAS).

PY - 2020/11

Y1 - 2020/11

N2 - Gut microbiota can be manipulated to benefit host health, including the use of probiotics, prebiotics and synbiotics. This Consensus Statement outlines the definition and scope of the term 'synbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in May 2019.In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

AB - Gut microbiota can be manipulated to benefit host health, including the use of probiotics, prebiotics and synbiotics. This Consensus Statement outlines the definition and scope of the term 'synbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in May 2019.In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

KW - RANDOMIZED CLINICAL-TRIAL

KW - IRRITABLE-BOWEL-SYNDROME

KW - FATTY LIVER-DISEASE

KW - DOUBLE-BLIND

KW - GUT MICROBIOTA

KW - ATOPIC-DERMATITIS

KW - OXIDATIVE STRESS

KW - POSTOPERATIVE COMPLICATIONS

KW - INFECTIOUS COMPLICATIONS

KW - BIFIDOBACTERIUM-LONGUM

UR - http://www.scopus.com/inward/record.url?scp=85089743727&partnerID=8YFLogxK

U2 - 10.1038/s41575-020-0344-2

DO - 10.1038/s41575-020-0344-2

M3 - Article

C2 - 32826966

SN - 1759-5045

VL - 17

SP - 687

EP - 701

JO - Nature Reviews Gastroenterology & Hepatology

JF - Nature Reviews Gastroenterology & Hepatology

IS - 11

ER -

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this