Abstract
Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the local microbiota. We report that chronic infection with the murine helminth Heligmosomoides polygyrus bakeri (Hpb) altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production. Transfer of the Hpb-modified microbiota alone was sufficient to mediate protection against allergic asthma. The helminth-induced anti-inflammatory cytokine secretion and regulatory T cell suppressor activity that mediated the protection required the G protein-coupled receptor (GPR)-41. A similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 998-1010 |
| Number of pages | 13 |
| Journal | Immunity |
| Volume | 43 |
| Issue number | 5 |
| Early online date | 27 Oct 2015 |
| DOIs | |
| Publication status | Published - 17 Nov 2015 |
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The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. / Zaiss, Mario M; Rapin, Alexis; Lebon, Luc; Dubey, Lalit Kumar; Mosconi, Ilaria; Sarter, Kerstin; Piersigilli, Alessandra; Menin, Laure; Walker, Alan W; Rougemont, Jacques; Paerewijck, Oonagh; Geldhof, Peter; McCoy, Kathleen D; Macpherson, Andrew J; Croese, John; Giacomin, Paul R; Loukas, Alex; Junt, Tobias; Marsland, Benjamin J; Harris, Nicola L (Corresponding Author).
In: Immunity, Vol. 43, No. 5, 17.11.2015, p. 998-1010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation
AU - Zaiss, Mario M
AU - Rapin, Alexis
AU - Lebon, Luc
AU - Dubey, Lalit Kumar
AU - Mosconi, Ilaria
AU - Sarter, Kerstin
AU - Piersigilli, Alessandra
AU - Menin, Laure
AU - Walker, Alan W
AU - Rougemont, Jacques
AU - Paerewijck, Oonagh
AU - Geldhof, Peter
AU - McCoy, Kathleen D
AU - Macpherson, Andrew J
AU - Croese, John
AU - Giacomin, Paul R
AU - Loukas, Alex
AU - Junt, Tobias
AU - Marsland, Benjamin J
AU - Harris, Nicola L
N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. Open Access funded by European Research Council. Sequence data are available at the European Nucleotide Archive (ENA): PRJEB10642.
PY - 2015/11/17
Y1 - 2015/11/17
N2 - Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the local microbiota. We report that chronic infection with the murine helminth Heligmosomoides polygyrus bakeri (Hpb) altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production. Transfer of the Hpb-modified microbiota alone was sufficient to mediate protection against allergic asthma. The helminth-induced anti-inflammatory cytokine secretion and regulatory T cell suppressor activity that mediated the protection required the G protein-coupled receptor (GPR)-41. A similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.
AB - Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the local microbiota. We report that chronic infection with the murine helminth Heligmosomoides polygyrus bakeri (Hpb) altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production. Transfer of the Hpb-modified microbiota alone was sufficient to mediate protection against allergic asthma. The helminth-induced anti-inflammatory cytokine secretion and regulatory T cell suppressor activity that mediated the protection required the G protein-coupled receptor (GPR)-41. A similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.
U2 - 10.1016/j.immuni.2015.09.012
DO - 10.1016/j.immuni.2015.09.012
M3 - Article
VL - 43
SP - 998
EP - 1010
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 5
ER -