The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses

Valerie Gaboriau-Routhiau, Sabine Rakotobe, Emelyne Lecuyer, Imke Mulder, Annaig Lan, Chantal Bridonneau, Violaine Rochet, Annamaria Pisi, Marianne De Paepe, Giovanni Brandi, Gerard Eberl, Johannes Snel, Denise Kelly, Nadine Cerf-Bensussan

Research output: Contribution to journalArticle

863 Citations (Scopus)

Abstract

Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine balance at steady-state and the role of individual bacterial species in setting the balance remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. This function appeared the prerogative of a restricted number of bacteria, the prototype of which is the segmented filamentous bacterium, a nonculturable Clostridia-related species, which could largely recapitulate the coordinated maturation of T cell responses induced by the whole mouse microbiota. This bacterium, already known as a potent inducer of mucosal IgA, likely plays a unique role in the postnatal maturation of gut immune functions. Changes in the infant flora may thus influence the development of host immune responses.

Original languageEnglish
Pages (from-to)677-689
Number of pages13
JournalImmunity
Volume31
Issue number4
DOIs
Publication statusPublished - 16 Oct 2009

Keywords

  • mucosal immune-system
  • commensal bacteria
  • intestinal bacteria
  • Lamina propria
  • microbiota
  • mice
  • homeostasis
  • IGA
  • differentiation
  • disease
  • MOLIMMUNO
  • MICROBIO

Cite this

Gaboriau-Routhiau, V., Rakotobe, S., Lecuyer, E., Mulder, I., Lan, A., Bridonneau, C., ... Cerf-Bensussan, N. (2009). The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity, 31(4), 677-689. https://doi.org/10.1016/j.immuni.2009.08.020