The link between ankylosing spondylitis and oral health conditions

two nested case-control studies using data of the UK Biobank

Hadeel Mohammed Abbood (Corresponding Author), Ejaz Pathan, George P. Cherukara

Research output: Contribution to journalArticle

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Abstract

Ankylosing Spondylitis (AS) is an inflammatory rheumatic disease that affects the axial skeleton and the sacroiliac joints. Recent studies investigated the link between AS and oral diseases, particularly periodontitis. Others suggested that periodontitis may have a role in the pathogenesis of rheumatic diseases. Objective: The aim of this study is to investigate the association between AS and oral conditions. Material and Methods: This research was conducted using the UK Biobank Resource under Application Number 26307. The UK Biobank recruited around 500000 participants throughout Great Britain. Clinical records were available for 2734 participants. Two case-control studies were conducted based on whether AS was self-reported or clinically diagnosed. Oral conditions were identified using self-reported reports of oral ulcers, painful gums, bleeding gums, loose teeth, toothache, and dentures. The association between AS and oral conditions was assessed using logistic regression adjusted for age, gender, educational level, smoking status, alcohol consumption, and body mass index. Results: A total of 1307 cases and 491503 control participants were eligible for the self-reported AS study. The mean age was 58 years for the cases [7.5 standard deviation (SD)] and 57 years for the control groups (8.1 SD). Also, 37.1% of the cases and 54.2% of the control participants were females. Among the oral conditions, only oral ulcers were strongly associated with AS [1.57 adjusted odds ratio (OR); 95% confidence interval (CI) 1.31 to 1.88]. For the study of clinically diagnosed AS, 153 cases and 490351 control participants were identified. The mean age for both cases and control groups was 57 years; 7.6 SD for the cases and 8.1 for the control group. Females corresponded to 26.1% of the cases, and 54.2% of the control participants. Clinically diagnosed AS was associated with self-reported oral ulcers (2.17 adjusted OR; 95% CI 1.33 to 3.53). Conclusion: Self-reported and clinically diagnosed AS populations have increased risk of reporting oral ulcers. Further investigations are required to assess the link between a specific type of oral condition and AS.
Original languageEnglish
Article numbere20180207
Number of pages10
JournalJournal of Applied Oral Science
Volume27
Early online date8 Nov 2018
DOIs
Publication statusPublished - 2019

Fingerprint

Ankylosing Spondylitis
Oral Health
Case-Control Studies
Oral Ulcer
Periodontitis
Gingiva
Rheumatic Diseases
Control Groups
Mouth Diseases
Odds Ratio
Toothache
Confidence Intervals
Sacroiliac Joint
Dentures
Skeleton
Alcohol Drinking
Self Report
Tooth
Body Mass Index
Logistic Models

Keywords

  • Ankylosing spondylitis
  • oral health
  • oral ulcers
  • epidemiology
  • Oral Health/statistics & numerical data
  • Prevalence
  • Humans
  • Middle Aged
  • Periodontitis/etiology
  • Risk Factors
  • Self Report
  • Medical Records
  • Logistic Models
  • Male
  • Case-Control Studies
  • United Kingdom/epidemiology
  • Oral Ulcer/epidemiology
  • Biological Specimen Banks
  • Adult
  • Female
  • Aged
  • Spondylitis, Ankylosing/complications
  • POPULATION
  • METAANALYSIS
  • PREVALENCE
  • Epidemiology
  • RHEUMATIC-DISEASES
  • VALIDITY
  • MANIFESTATIONS
  • DIAGNOSIS
  • PARAMETERS
  • CHRONIC PERIODONTITIS
  • Oral ulcers
  • Oral health

Cite this

The link between ankylosing spondylitis and oral health conditions : two nested case-control studies using data of the UK Biobank. / Abbood, Hadeel Mohammed (Corresponding Author); Pathan, Ejaz; Cherukara, George P.

In: Journal of Applied Oral Science, Vol. 27, e20180207, 2019.

Research output: Contribution to journalArticle

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title = "The link between ankylosing spondylitis and oral health conditions: two nested case-control studies using data of the UK Biobank",
abstract = "Ankylosing Spondylitis (AS) is an inflammatory rheumatic disease that affects the axial skeleton and the sacroiliac joints. Recent studies investigated the link between AS and oral diseases, particularly periodontitis. Others suggested that periodontitis may have a role in the pathogenesis of rheumatic diseases. Objective: The aim of this study is to investigate the association between AS and oral conditions. Material and Methods: This research was conducted using the UK Biobank Resource under Application Number 26307. The UK Biobank recruited around 500000 participants throughout Great Britain. Clinical records were available for 2734 participants. Two case-control studies were conducted based on whether AS was self-reported or clinically diagnosed. Oral conditions were identified using self-reported reports of oral ulcers, painful gums, bleeding gums, loose teeth, toothache, and dentures. The association between AS and oral conditions was assessed using logistic regression adjusted for age, gender, educational level, smoking status, alcohol consumption, and body mass index. Results: A total of 1307 cases and 491503 control participants were eligible for the self-reported AS study. The mean age was 58 years for the cases [7.5 standard deviation (SD)] and 57 years for the control groups (8.1 SD). Also, 37.1{\%} of the cases and 54.2{\%} of the control participants were females. Among the oral conditions, only oral ulcers were strongly associated with AS [1.57 adjusted odds ratio (OR); 95{\%} confidence interval (CI) 1.31 to 1.88]. For the study of clinically diagnosed AS, 153 cases and 490351 control participants were identified. The mean age for both cases and control groups was 57 years; 7.6 SD for the cases and 8.1 for the control group. Females corresponded to 26.1{\%} of the cases, and 54.2{\%} of the control participants. Clinically diagnosed AS was associated with self-reported oral ulcers (2.17 adjusted OR; 95{\%} CI 1.33 to 3.53). Conclusion: Self-reported and clinically diagnosed AS populations have increased risk of reporting oral ulcers. Further investigations are required to assess the link between a specific type of oral condition and AS.",
keywords = "Ankylosing spondylitis, oral health, oral ulcers, epidemiology, Oral Health/statistics & numerical data, Prevalence, Humans, Middle Aged, Periodontitis/etiology, Risk Factors, Self Report, Medical Records, Logistic Models, Male, Case-Control Studies, United Kingdom/epidemiology, Oral Ulcer/epidemiology, Biological Specimen Banks, Adult, Female, Aged, Spondylitis, Ankylosing/complications, POPULATION, METAANALYSIS, PREVALENCE, Epidemiology, RHEUMATIC-DISEASES, VALIDITY, MANIFESTATIONS, DIAGNOSIS, PARAMETERS, CHRONIC PERIODONTITIS, Oral ulcers, Oral health",
author = "Abbood, {Hadeel Mohammed} and Ejaz Pathan and Cherukara, {George P.}",
note = "This research has been conducted using the UK Biobank Resource under Application Number 26307. The authors declare that they have no competing interests. HMA received funding from the Higher Committee for Education Development in Iraq (HCED-Iraq) to undertake her PhD. The authors are grateful to Professor Gary Macfarlane (Epidemiology Group, University of Aberdeen) for his valuable comments and suggestions on the analysis and the draft of manuscript.",
year = "2019",
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journal = "Journal of Applied Oral Science",
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T2 - two nested case-control studies using data of the UK Biobank

AU - Abbood, Hadeel Mohammed

AU - Pathan, Ejaz

AU - Cherukara, George P.

N1 - This research has been conducted using the UK Biobank Resource under Application Number 26307. The authors declare that they have no competing interests. HMA received funding from the Higher Committee for Education Development in Iraq (HCED-Iraq) to undertake her PhD. The authors are grateful to Professor Gary Macfarlane (Epidemiology Group, University of Aberdeen) for his valuable comments and suggestions on the analysis and the draft of manuscript.

PY - 2019

Y1 - 2019

N2 - Ankylosing Spondylitis (AS) is an inflammatory rheumatic disease that affects the axial skeleton and the sacroiliac joints. Recent studies investigated the link between AS and oral diseases, particularly periodontitis. Others suggested that periodontitis may have a role in the pathogenesis of rheumatic diseases. Objective: The aim of this study is to investigate the association between AS and oral conditions. Material and Methods: This research was conducted using the UK Biobank Resource under Application Number 26307. The UK Biobank recruited around 500000 participants throughout Great Britain. Clinical records were available for 2734 participants. Two case-control studies were conducted based on whether AS was self-reported or clinically diagnosed. Oral conditions were identified using self-reported reports of oral ulcers, painful gums, bleeding gums, loose teeth, toothache, and dentures. The association between AS and oral conditions was assessed using logistic regression adjusted for age, gender, educational level, smoking status, alcohol consumption, and body mass index. Results: A total of 1307 cases and 491503 control participants were eligible for the self-reported AS study. The mean age was 58 years for the cases [7.5 standard deviation (SD)] and 57 years for the control groups (8.1 SD). Also, 37.1% of the cases and 54.2% of the control participants were females. Among the oral conditions, only oral ulcers were strongly associated with AS [1.57 adjusted odds ratio (OR); 95% confidence interval (CI) 1.31 to 1.88]. For the study of clinically diagnosed AS, 153 cases and 490351 control participants were identified. The mean age for both cases and control groups was 57 years; 7.6 SD for the cases and 8.1 for the control group. Females corresponded to 26.1% of the cases, and 54.2% of the control participants. Clinically diagnosed AS was associated with self-reported oral ulcers (2.17 adjusted OR; 95% CI 1.33 to 3.53). Conclusion: Self-reported and clinically diagnosed AS populations have increased risk of reporting oral ulcers. Further investigations are required to assess the link between a specific type of oral condition and AS.

AB - Ankylosing Spondylitis (AS) is an inflammatory rheumatic disease that affects the axial skeleton and the sacroiliac joints. Recent studies investigated the link between AS and oral diseases, particularly periodontitis. Others suggested that periodontitis may have a role in the pathogenesis of rheumatic diseases. Objective: The aim of this study is to investigate the association between AS and oral conditions. Material and Methods: This research was conducted using the UK Biobank Resource under Application Number 26307. The UK Biobank recruited around 500000 participants throughout Great Britain. Clinical records were available for 2734 participants. Two case-control studies were conducted based on whether AS was self-reported or clinically diagnosed. Oral conditions were identified using self-reported reports of oral ulcers, painful gums, bleeding gums, loose teeth, toothache, and dentures. The association between AS and oral conditions was assessed using logistic regression adjusted for age, gender, educational level, smoking status, alcohol consumption, and body mass index. Results: A total of 1307 cases and 491503 control participants were eligible for the self-reported AS study. The mean age was 58 years for the cases [7.5 standard deviation (SD)] and 57 years for the control groups (8.1 SD). Also, 37.1% of the cases and 54.2% of the control participants were females. Among the oral conditions, only oral ulcers were strongly associated with AS [1.57 adjusted odds ratio (OR); 95% confidence interval (CI) 1.31 to 1.88]. For the study of clinically diagnosed AS, 153 cases and 490351 control participants were identified. The mean age for both cases and control groups was 57 years; 7.6 SD for the cases and 8.1 for the control group. Females corresponded to 26.1% of the cases, and 54.2% of the control participants. Clinically diagnosed AS was associated with self-reported oral ulcers (2.17 adjusted OR; 95% CI 1.33 to 3.53). Conclusion: Self-reported and clinically diagnosed AS populations have increased risk of reporting oral ulcers. Further investigations are required to assess the link between a specific type of oral condition and AS.

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KW - oral health

KW - oral ulcers

KW - epidemiology

KW - Oral Health/statistics & numerical data

KW - Prevalence

KW - Humans

KW - Middle Aged

KW - Periodontitis/etiology

KW - Risk Factors

KW - Self Report

KW - Medical Records

KW - Logistic Models

KW - Male

KW - Case-Control Studies

KW - United Kingdom/epidemiology

KW - Oral Ulcer/epidemiology

KW - Biological Specimen Banks

KW - Adult

KW - Female

KW - Aged

KW - Spondylitis, Ankylosing/complications

KW - POPULATION

KW - METAANALYSIS

KW - PREVALENCE

KW - Epidemiology

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KW - VALIDITY

KW - MANIFESTATIONS

KW - DIAGNOSIS

KW - PARAMETERS

KW - CHRONIC PERIODONTITIS

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JO - Journal of Applied Oral Science

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