The mannose receptor, a bi-functional lectin with roles in homeostasis and immunity

Emma Jane McKenzie, Y. -. P. Su, L. Martinez-Pomares

    Research output: Contribution to journalEditorial

    10 Citations (Scopus)

    Abstract

    The mannose receptor (MR) is a unique bi-functional molecule with two lectin activities. Its N-terminal cysteine-rich (CR) domain exclusively recognises endogenous acidic glycans, while its C-type-lectin domains (CRDs) bind carbohydrates decorating some microbial surfaces, as well as some secreted endogenous glycoproteins that are cleared through this receptor. In this review we aim to provide an update on some aspects of MR biology with special emphasis on its role in clearance (when expressed in tissue macrophages (M) and sinusoidal endothelia), antigen delivery (as cell associated form on dendritic cells (DCs), or through targeting of its soluble form to lymphoid organs) and cell adhesion (when expressed by lymphatic endothelia).

    Original languageEnglish
    Pages (from-to)273-283
    Number of pages10
    JournalTrends in Glycoscience and Glycotechnology
    Volume14
    Issue number79
    Publication statusPublished - 2002

    Keywords

    • lectins
    • antigen presentation
    • endocytosis microbe recognition
    • self-recognition
    • CYSTEINE-RICH DOMAIN
    • HUMAN DENDRITIC CELLS
    • MYCOBACTERIUM-TUBERCULOSIS INFECTION
    • CARBOHYDRATE-RECOGNITION DOMAINS
    • COLONY-STIMULATING FACTOR
    • MACROPHAGES IN-VITRO
    • PNEUMOCYSTIS-CARINII
    • ALVEOLAR MACROPHAGES
    • INTERFERON-GAMMA
    • DOWN-REGULATION

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