The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping

Design and multicenter pilot study

N. A. Weaver, L. Zhao, J. M. Biesbroek, H. J. Kuijf, H. P. Aben, H. J. Bae, M. A. A. Caballero, F. M. Chappell, Cplh Chen, M. Dichgans, M. Duering, M. K. Georgakis, R. S. van der Giessen, B. Gyanwali, O. K. L. Hamilton, S. Hilal, E. M. Vom Hofe, P. L. M. de Kort, P. J. Koudstaal, B. Y. K. Lam & 12 others J. S. Lim, S. D. J. Makin, V. C. T. Mok, L. Shi, M. C. Valdes Hernandez, N. Venketasubramanian, J. M. Wardlaw, F. A. Wollenweber, A. Wong, X. Xin, V. C. I. Map consortium Meta, G. J. Biessels

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
Original languageEnglish
Pages (from-to)310-326
Number of pages17
JournalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume11
Early online date12 Apr 2019
DOIs
Publication statusE-pub ahead of print - 12 Apr 2019

Fingerprint

Multicenter Studies
Blood Vessels
Meta-Analysis
Stroke
Sample Size
Tomography
Research Personnel
Magnetic Resonance Imaging
Brain
Population
Cognitive Dysfunction
White Matter

Keywords

  • Cerebrovascular disease Consortium Data harmonization Lesion location Lesion-symptom mapping Small vessel disease Stroke Support vector regression Vascular cognitive impairment
  • Lesion-symptom mapping
  • Stroke
  • Small vessel disease
  • Lesion location
  • Vascular cognitive impairment
  • Consortium
  • Support vector regression
  • Data harmonization
  • Cerebrovascular disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping : Design and multicenter pilot study. / Weaver, N. A.; Zhao, L.; Biesbroek, J. M.; Kuijf, H. J.; Aben, H. P.; Bae, H. J.; Caballero, M. A. A.; Chappell, F. M.; Chen, Cplh; Dichgans, M.; Duering, M.; Georgakis, M. K.; van der Giessen, R. S.; Gyanwali, B.; Hamilton, O. K. L.; Hilal, S.; Vom Hofe, E. M.; de Kort, P. L. M.; Koudstaal, P. J.; Lam, B. Y. K.; Lim, J. S.; Makin, S. D. J.; Mok, V. C. T.; Shi, L.; Valdes Hernandez, M. C.; Venketasubramanian, N.; Wardlaw, J. M.; Wollenweber, F. A.; Wong, A.; Xin, X.; Meta, V. C. I. Map consortium; Biessels, G. J.

In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 11, 12.2019, p. 310-326.

Research output: Contribution to journalArticle

Weaver, NA, Zhao, L, Biesbroek, JM, Kuijf, HJ, Aben, HP, Bae, HJ, Caballero, MAA, Chappell, FM, Chen, C, Dichgans, M, Duering, M, Georgakis, MK, van der Giessen, RS, Gyanwali, B, Hamilton, OKL, Hilal, S, Vom Hofe, EM, de Kort, PLM, Koudstaal, PJ, Lam, BYK, Lim, JS, Makin, SDJ, Mok, VCT, Shi, L, Valdes Hernandez, MC, Venketasubramanian, N, Wardlaw, JM, Wollenweber, FA, Wong, A, Xin, X, Meta, VCIMC & Biessels, GJ 2019, 'The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 11, pp. 310-326. https://doi.org/10.1016/j.dadm.2019.02.007
Weaver, N. A. ; Zhao, L. ; Biesbroek, J. M. ; Kuijf, H. J. ; Aben, H. P. ; Bae, H. J. ; Caballero, M. A. A. ; Chappell, F. M. ; Chen, Cplh ; Dichgans, M. ; Duering, M. ; Georgakis, M. K. ; van der Giessen, R. S. ; Gyanwali, B. ; Hamilton, O. K. L. ; Hilal, S. ; Vom Hofe, E. M. ; de Kort, P. L. M. ; Koudstaal, P. J. ; Lam, B. Y. K. ; Lim, J. S. ; Makin, S. D. J. ; Mok, V. C. T. ; Shi, L. ; Valdes Hernandez, M. C. ; Venketasubramanian, N. ; Wardlaw, J. M. ; Wollenweber, F. A. ; Wong, A. ; Xin, X. ; Meta, V. C. I. Map consortium ; Biessels, G. J. / The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping : Design and multicenter pilot study. In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2019 ; Vol. 11. pp. 310-326.
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title = "The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study",
abstract = "Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.",
keywords = "Cerebrovascular disease Consortium Data harmonization Lesion location Lesion-symptom mapping Small vessel disease Stroke Support vector regression Vascular cognitive impairment, Lesion-symptom mapping, Stroke, Small vessel disease, Lesion location, Vascular cognitive impairment, Consortium, Support vector regression, Data harmonization, Cerebrovascular disease",
author = "Weaver, {N. A.} and L. Zhao and Biesbroek, {J. M.} and Kuijf, {H. J.} and Aben, {H. P.} and Bae, {H. J.} and Caballero, {M. A. A.} and Chappell, {F. M.} and Cplh Chen and M. Dichgans and M. Duering and Georgakis, {M. K.} and {van der Giessen}, {R. S.} and B. Gyanwali and Hamilton, {O. K. L.} and S. Hilal and {Vom Hofe}, {E. M.} and {de Kort}, {P. L. M.} and Koudstaal, {P. J.} and Lam, {B. Y. K.} and Lim, {J. S.} and Makin, {S. D. J.} and Mok, {V. C. T.} and L. Shi and {Valdes Hernandez}, {M. C.} and N. Venketasubramanian and Wardlaw, {J. M.} and Wollenweber, {F. A.} and A. Wong and X. Xin and Meta, {V. C. I. Map consortium} and Biessels, {G. J.}",
note = "Additional grant support pilot study cohorts: The CODECS study is supported by a grant from Stichting Coolsingel, the Netherlands. Funding for the PROCRAS study was obtained through ZonMw as part of the ‘TopZorg’ project in 2015 (grant # 842003011). The CU-STRIDE study was funded by the Health and Health Services Research Fund (0708041) of the Food and Health Bureau of the Government of the Hong Kong Special Administrative Region. The CU-RISK study was funded by General Research Fund (grant number GRF CUHK 471911), the National Key Research and Development Program of China (grant number 2016YFC1300600), and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Center for Prevention of Dementia (in memory of Donald H. K. Chow). The Mild Stroke Study 2 was funded by the Wellcome Trust (WT088134/Z/09/A), the Row Fogo Charitable Trust and Chest Heart & Stroke Scotland (long-term follow-up, ref no: Res14/A157). J.M.W. is supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (ref no. 16 CVD 05) and the UK Dementia Research Institute at The University of Edinburgh. O.K.L.H. is supported by the College of Medicine and Veterinary Medicine at the University of Edinburgh and the Wellcome Trust.",
year = "2019",
month = "4",
day = "12",
doi = "10.1016/j.dadm.2019.02.007",
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TY - JOUR

T1 - The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping

T2 - Design and multicenter pilot study

AU - Weaver, N. A.

AU - Zhao, L.

AU - Biesbroek, J. M.

AU - Kuijf, H. J.

AU - Aben, H. P.

AU - Bae, H. J.

AU - Caballero, M. A. A.

AU - Chappell, F. M.

AU - Chen, Cplh

AU - Dichgans, M.

AU - Duering, M.

AU - Georgakis, M. K.

AU - van der Giessen, R. S.

AU - Gyanwali, B.

AU - Hamilton, O. K. L.

AU - Hilal, S.

AU - Vom Hofe, E. M.

AU - de Kort, P. L. M.

AU - Koudstaal, P. J.

AU - Lam, B. Y. K.

AU - Lim, J. S.

AU - Makin, S. D. J.

AU - Mok, V. C. T.

AU - Shi, L.

AU - Valdes Hernandez, M. C.

AU - Venketasubramanian, N.

AU - Wardlaw, J. M.

AU - Wollenweber, F. A.

AU - Wong, A.

AU - Xin, X.

AU - Meta, V. C. I. Map consortium

AU - Biessels, G. J.

N1 - Additional grant support pilot study cohorts: The CODECS study is supported by a grant from Stichting Coolsingel, the Netherlands. Funding for the PROCRAS study was obtained through ZonMw as part of the ‘TopZorg’ project in 2015 (grant # 842003011). The CU-STRIDE study was funded by the Health and Health Services Research Fund (0708041) of the Food and Health Bureau of the Government of the Hong Kong Special Administrative Region. The CU-RISK study was funded by General Research Fund (grant number GRF CUHK 471911), the National Key Research and Development Program of China (grant number 2016YFC1300600), and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Center for Prevention of Dementia (in memory of Donald H. K. Chow). The Mild Stroke Study 2 was funded by the Wellcome Trust (WT088134/Z/09/A), the Row Fogo Charitable Trust and Chest Heart & Stroke Scotland (long-term follow-up, ref no: Res14/A157). J.M.W. is supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (ref no. 16 CVD 05) and the UK Dementia Research Institute at The University of Edinburgh. O.K.L.H. is supported by the College of Medicine and Veterinary Medicine at the University of Edinburgh and the Wellcome Trust.

PY - 2019/4/12

Y1 - 2019/4/12

N2 - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

AB - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

KW - Cerebrovascular disease Consortium Data harmonization Lesion location Lesion-symptom mapping Small vessel disease Stroke Support vector regression Vascular cognitive impairment

KW - Lesion-symptom mapping

KW - Stroke

KW - Small vessel disease

KW - Lesion location

KW - Vascular cognitive impairment

KW - Consortium

KW - Support vector regression

KW - Data harmonization

KW - Cerebrovascular disease

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