THE METABOLIC-FATE OF [H-3] ESTRADIOL IN RELATION TO DIETARY-INTAKE OF BORON IN OVARIECTOMIZED RATS

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.

    Original languageEnglish
    Pages (from-to)549-554
    Number of pages6
    JournalThe Journal of Steroid Biochemistry and Molecular Biology
    Volume45
    Issue number6
    Publication statusPublished - Jun 1993

    Keywords

    • ESTROGENS

    Cite this

    @article{6c8084ac88a945cc87e351e6b555a13d,
    title = "THE METABOLIC-FATE OF [H-3] ESTRADIOL IN RELATION TO DIETARY-INTAKE OF BORON IN OVARIECTOMIZED RATS",
    abstract = "It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.",
    keywords = "ESTROGENS",
    author = "BEATTIE, {J H}",
    year = "1993",
    month = "6",
    language = "English",
    volume = "45",
    pages = "549--554",
    journal = "The Journal of Steroid Biochemistry and Molecular Biology",
    issn = "0960-0760",
    publisher = "Elsevier Limited",
    number = "6",

    }

    TY - JOUR

    T1 - THE METABOLIC-FATE OF [H-3] ESTRADIOL IN RELATION TO DIETARY-INTAKE OF BORON IN OVARIECTOMIZED RATS

    AU - BEATTIE, J H

    PY - 1993/6

    Y1 - 1993/6

    N2 - It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.

    AB - It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.

    KW - ESTROGENS

    M3 - Article

    VL - 45

    SP - 549

    EP - 554

    JO - The Journal of Steroid Biochemistry and Molecular Biology

    JF - The Journal of Steroid Biochemistry and Molecular Biology

    SN - 0960-0760

    IS - 6

    ER -