It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.
|Number of pages||6|
|Journal||The Journal of Steroid Biochemistry and Molecular Biology|
|Publication status||Published - Jun 1993|