The Microbiota of the Human Gastrointestinal Tract: A Molecular View

Kieran M. Tuohy*, Karen P. Scott

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The human gut microbiota represents a complex collection of microorganisms, which contribute considerably to host health. They occupy different ecological niches and habitats within the gastrointestinal tract and vary both in compositional make up and metabolic output at different sites along the gut. In this chapter, we describe the microbial "geography" within the human gastrointestinal tract and discuss available methods for studying the gut microbiota at both taxonomic and metabolic levels. Tremendous advances have been made in culture independent molecular microbiology over the past 20 years giving previously undreamt of insight into the architecture of the gut microbiota. Similarly, advances in "omics" technologies, especially metagenomics and metabolomics, are providing the tools necessary to give, for the first time, a real insight into both the gut microbiota metabolic potential (encoded by the genes of microbiota metagenome) and the metabolic kinetic (comprising the flux of microbially derived metabolites) and how these then interact with host physiology influencing health and disease risk.

Original languageEnglish
Title of host publicationDiet-Microbe Interactions in the Gut
Subtitle of host publicationEffects on Human Health and Disease
PublisherElsevier Inc.
Pages1-15
Number of pages15
ISBN (Electronic)9780124079410
ISBN (Print)9780124078253
DOIs
Publication statusPublished - 2015

Keywords

  • Colon
  • FISH
  • Gut microbiota
  • Gut models
  • Metabolomics
  • Metabonomics
  • Metagenomics
  • PCR
  • Small intestine
  • Stomach

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Tuohy, K. M., & Scott, K. P. (2015). The Microbiota of the Human Gastrointestinal Tract: A Molecular View. In Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease (pp. 1-15). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-407825-3.00001-0