The Mitochondrial Contribution to Animal Performance, Adaptation, and Life-History Variation

Wendy R. Hood (Corresponding Author), Steven N. Austad, Pierre Bize, Ana Gabriela  Jimenez, Kristi L.  Montooth, Patricia M Schulte, Graham R.  Scott, Inna  Sokolova, Jason R.  Treberg, Karine Salin (Corresponding Author)

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Animals display tremendous variation in their rates of growth, reproductive output, and longevity. While the physiological and molecular mechanisms that underlie this variation remain poorly understood, the performance of the mitochondrion has emerged as a key player. Mitochondria not only impact the performance of eukaryotes via their capacity to produce ATP, but they also play a role in producing heat and reactive oxygen species and function as a major signalling hub for the cell. The papers included in this special issue emerged from a symposium titled “Inside the Black Box: The Mitochondrial Basis of Life-history Variation and Animal Performance”. Based on studies of diverse animal taxa, three distinct themes emerged from these papers. 1) When linking mitochondrial function to components of fitness, it is crucial that mitochondrial assays are performed in conditions as close as the intracellular conditions experienced by the mitochondria in vivo. 2) Functional plasticity allows mitochondria to retain their performance, as well as that of their host, over a range of exogenous conditions, and selection on mitochondrial and nuclear-derived proteins can optimize the match between the environment and the bioenergetic capacity of the mitochondrion. Finally, 3) studies of wild and wild-derived animals suggest that mitochondria play a central role in animal performance and life history strategy. Taken as a whole, we hope that these papers will foster discussion and inspire new hypotheses and innovations that will further our understanding of the mitochondrial processes that underlie variation in life history traits and animal performance.
Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalIntegrative and Comparative Biology
Volume58
Issue number3
Early online date5 Jul 2018
DOIs
Publication statusPublished - 1 Sep 2018

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animal performance
mitochondria
life history
animals
energy metabolism
eukaryotic cells
reactive oxygen species
reproductive performance
heat
assays
proteins
cells

Keywords

  • oxidative phosphorylation
  • reactive oxygen specie
  • mitonuclear (in)compatibility
  • trade-off
  • pace of life

Cite this

Hood, W. R., Austad, S. N., Bize, P., Jimenez, AG., Montooth, KL. ., Schulte, P. M., ... Salin, K. (2018). The Mitochondrial Contribution to Animal Performance, Adaptation, and Life-History Variation. Integrative and Comparative Biology, 58(3), 480-485. https://doi.org/10.1093/icb/icy089

The Mitochondrial Contribution to Animal Performance, Adaptation, and Life-History Variation. / Hood, Wendy R. (Corresponding Author); Austad, Steven N.; Bize, Pierre; Jimenez, Ana Gabriela  ; Montooth, Kristi L.  ; Schulte, Patricia M; Scott, Graham R. ; Sokolova, Inna ; Treberg, Jason R. ; Salin, Karine (Corresponding Author).

In: Integrative and Comparative Biology, Vol. 58, No. 3, 01.09.2018, p. 480-485.

Research output: Contribution to journalArticle

Hood, WR, Austad, SN, Bize, P, Jimenez, AG, Montooth, KL, Schulte, PM, Scott, GR, Sokolova, I, Treberg, JR & Salin, K 2018, 'The Mitochondrial Contribution to Animal Performance, Adaptation, and Life-History Variation', Integrative and Comparative Biology, vol. 58, no. 3, pp. 480-485. https://doi.org/10.1093/icb/icy089
Hood, Wendy R. ; Austad, Steven N. ; Bize, Pierre ; Jimenez, Ana Gabriela  ; Montooth, Kristi L.  ; Schulte, Patricia M ; Scott, Graham R.  ; Sokolova, Inna  ; Treberg, Jason R.  ; Salin, Karine. / The Mitochondrial Contribution to Animal Performance, Adaptation, and Life-History Variation. In: Integrative and Comparative Biology. 2018 ; Vol. 58, No. 3. pp. 480-485.
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abstract = "Animals display tremendous variation in their rates of growth, reproductive output, and longevity. While the physiological and molecular mechanisms that underlie this variation remain poorly understood, the performance of the mitochondrion has emerged as a key player. Mitochondria not only impact the performance of eukaryotes via their capacity to produce ATP, but they also play a role in producing heat and reactive oxygen species and function as a major signalling hub for the cell. The papers included in this special issue emerged from a symposium titled “Inside the Black Box: The Mitochondrial Basis of Life-history Variation and Animal Performance”. Based on studies of diverse animal taxa, three distinct themes emerged from these papers. 1) When linking mitochondrial function to components of fitness, it is crucial that mitochondrial assays are performed in conditions as close as the intracellular conditions experienced by the mitochondria in vivo. 2) Functional plasticity allows mitochondria to retain their performance, as well as that of their host, over a range of exogenous conditions, and selection on mitochondrial and nuclear-derived proteins can optimize the match between the environment and the bioenergetic capacity of the mitochondrion. Finally, 3) studies of wild and wild-derived animals suggest that mitochondria play a central role in animal performance and life history strategy. Taken as a whole, we hope that these papers will foster discussion and inspire new hypotheses and innovations that will further our understanding of the mitochondrial processes that underlie variation in life history traits and animal performance.",
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N1 - We thank the National Science Foundation (grant IOS1738378 to W.R.H. and K.S.), SICB’s division of Comparative Physiology and Biochemistry and Comparative Endocrinology, the Company of Biologists, the Society of Experimental Biology, and the Canadian Society of Zoology for funding the symposium.  

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N2 - Animals display tremendous variation in their rates of growth, reproductive output, and longevity. While the physiological and molecular mechanisms that underlie this variation remain poorly understood, the performance of the mitochondrion has emerged as a key player. Mitochondria not only impact the performance of eukaryotes via their capacity to produce ATP, but they also play a role in producing heat and reactive oxygen species and function as a major signalling hub for the cell. The papers included in this special issue emerged from a symposium titled “Inside the Black Box: The Mitochondrial Basis of Life-history Variation and Animal Performance”. Based on studies of diverse animal taxa, three distinct themes emerged from these papers. 1) When linking mitochondrial function to components of fitness, it is crucial that mitochondrial assays are performed in conditions as close as the intracellular conditions experienced by the mitochondria in vivo. 2) Functional plasticity allows mitochondria to retain their performance, as well as that of their host, over a range of exogenous conditions, and selection on mitochondrial and nuclear-derived proteins can optimize the match between the environment and the bioenergetic capacity of the mitochondrion. Finally, 3) studies of wild and wild-derived animals suggest that mitochondria play a central role in animal performance and life history strategy. Taken as a whole, we hope that these papers will foster discussion and inspire new hypotheses and innovations that will further our understanding of the mitochondrial processes that underlie variation in life history traits and animal performance.

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