The molecular evolution of the Interleukin-1 family of cytokines; IL-18 in teleost fish.

M. O. Huising, Rene Josephus Maria Stet, H. F. J. Savelkoul, B. M. L. Verburg-van Kemenade

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    128 Citations (Scopus)


    The cytokine network is an important homeostatic system with potent activities in immune surveillance, growth, developmental and repair processes. Although interleukin-1beta (IL-1beta) is considered a pivotal pro-inflammatory cytokine, merely focussing on its inflammatory role would be too narrow an approach. Elucidation of the human, the mouse and the Fugu rubripes (pufferfish) genome now enables a more comprehensive overview of this cytokine family and its receptors in several vertebrate classes. Phylogenetic analyses of the IL-1 family members, comprising over 80 sequences of various fish, amphibian, avian and mammalian species, reveal that for only a few mammalian IL-1 family members unambiguous orthologues have been found in fish, indicating a recent origin of some of the mammalian IL-1 family members. Interestingly, the Fugu genome did reveal teleost orthologues for IL-18 and its putative receptor complex. All teleost IL-1beta sequences Cluster separately from IL-1beta sequences of other species. In contrast, a number of IL-1 receptor family members have well conserved fish orthologues. This supports the concept of an ancestral role of this family, possibly in the brain. (C) 2003 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)395-413
    Number of pages18
    JournalDevelopmental and Comparative Immunology
    Publication statusPublished - 2004


    • IL-1
    • IL-18
    • interleukin-1 family
    • evolution
    • fish immune system
    • neuroendocrine-immune interaction
    • NF-KAPPA-B
    • IN-VITRO
    • IL-1-BETA


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