The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris

Klara Junker; Gustavo Bravo Ruiz; Alexander Lorenz; Louise Walker; Neil Gow; Jürgen Wendland

doi:10.1038/s41598-018-33199-z

The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris

Klara Junker, Gustavo Bravo Ruiz, Alexander Lorenz, Louise Walker, Neil Gow, Jürgen Wendland (Corresponding Author)

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Abstract

Candida auris has recently emerged as a multi-drug resistant fungal pathogen that poses a serious global health threat, especially for patients in hospital intensive care units (ICUs). C. auris can colonize human skin and can spread by physical contact or contaminated surfaces and equipment. Here, we show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills multi-drug resistant both sensitive and multi-drug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol.

Original language	English
Article number	14959
Number of pages	5
Journal	Scientific Reports
Volume	8
DOIs	https://doi.org/10.1038/s41598-018-33199-z
Publication status	Published - 8 Oct 2018

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The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris
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Alexander Lorenz
- School of Medicine, Medical Sciences & Nutrition, Medical Sciences - Senior Lecturer
- Institute of Medical Sciences
Person: Academic

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title = "The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris",

abstract = "Candida auris has recently emerged as a multi-drug resistant fungal pathogen that poses a serious global health threat, especially for patients in hospital intensive care units (ICUs). C. auris can colonize human skin and can spread by physical contact or contaminated surfaces and equipment. Here, we show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills multi-drug resistant both sensitive and multi-drug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol.",

author = "Klara Junker and {Bravo Ruiz}, Gustavo and Alexander Lorenz and Louise Walker and Neil Gow and J{\"u}rgen Wendland",

note = "EU Marie Curie ITN Fungibrain (607963), the Wellcome Trust (204815/Z/16/Z, 080088, 086827, 075470, 099215, and 097377), MRC Centre for Medical Mycology at the University of Aberdeen (MR/N006364/1).",

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T1 - The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris

AU - Junker, Klara

AU - Bravo Ruiz, Gustavo

AU - Lorenz, Alexander

AU - Walker, Louise

AU - Gow, Neil

AU - Wendland, Jürgen

N1 - EU Marie Curie ITN Fungibrain (607963), the Wellcome Trust (204815/Z/16/Z, 080088, 086827, 075470, 099215, and 097377), MRC Centre for Medical Mycology at the University of Aberdeen (MR/N006364/1).

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N2 - Candida auris has recently emerged as a multi-drug resistant fungal pathogen that poses a serious global health threat, especially for patients in hospital intensive care units (ICUs). C. auris can colonize human skin and can spread by physical contact or contaminated surfaces and equipment. Here, we show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills multi-drug resistant both sensitive and multi-drug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol.

AB - Candida auris has recently emerged as a multi-drug resistant fungal pathogen that poses a serious global health threat, especially for patients in hospital intensive care units (ICUs). C. auris can colonize human skin and can spread by physical contact or contaminated surfaces and equipment. Here, we show that the mycoparasitic yeast Saccharomycopsis schoenii efficiently kills multi-drug resistant both sensitive and multi-drug resistant isolates of C. auris belonging to the same clade, as well as clinical isolates of other pathogenic species of the Candida genus suggesting novel approaches for biocontrol.

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DO - 10.1038/s41598-018-33199-z

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JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 14959

ER -

The mycoparasitic yeast Saccharomycopsis schoenii predates and kills multi-drug resistant Candida auris

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