The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

Fiona Margaret Campbell, M Waterston, L O Andresen, N S Sorensen, P M H Heegaard, P D Eckersall

    Research output: Contribution to journalArticle

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    Abstract

    Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

    Original languageEnglish
    Pages (from-to)657-664
    Number of pages8
    JournalVeterinary Research
    Volume36
    Issue number4
    DOIs
    Publication statusPublished - 2005

    Keywords

    • acute phase proteins
    • pigs
    • infection Streptococcus suis
    • ACTINOBACILLUS-PLEUROPNEUMONIAE INFECTION
    • C-REACTIVE PROTEIN
    • HAPTOGLOBIN CONCENTRATION
    • PREALBUMIN
    • STANDARDIZATION
    • INTERLEUKIN-6
    • MARKER
    • HEALTH
    • acute phase proteins
    • infection Streptococcus suis

    Cite this

    The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig. / Campbell, Fiona Margaret; Waterston, M ; Andresen, L O ; Sorensen, N S ; Heegaard, P M H ; Eckersall, P D .

    In: Veterinary Research, Vol. 36, No. 4, 2005, p. 657-664.

    Research output: Contribution to journalArticle

    Campbell, Fiona Margaret ; Waterston, M ; Andresen, L O ; Sorensen, N S ; Heegaard, P M H ; Eckersall, P D . / The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig. In: Veterinary Research. 2005 ; Vol. 36, No. 4. pp. 657-664.
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    abstract = "Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.",
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    AU - Campbell, Fiona Margaret

    AU - Waterston, M

    AU - Andresen, L O

    AU - Sorensen, N S

    AU - Heegaard, P M H

    AU - Eckersall, P D

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    AB - Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

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    KW - C-REACTIVE PROTEIN

    KW - HAPTOGLOBIN CONCENTRATION

    KW - PREALBUMIN

    KW - STANDARDIZATION

    KW - INTERLEUKIN-6

    KW - MARKER

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