The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

Fiona Margaret Campbell; M  Waterston; L O  Andresen; N S  Sorensen; P M H  Heegaard; P D  Eckersall

doi:10.1051/vetres:2005017

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

Fiona Margaret Campbell, M Waterston, L O Andresen, N S Sorensen, P M H Heegaard, P D Eckersall

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Abstract

Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

Original language	English
Pages (from-to)	657-664
Number of pages	8
Journal	Veterinary Research
Volume	36
Issue number	4
DOIs	https://doi.org/10.1051/vetres:2005017
Publication status	Published - 2005

Keywords

acute phase proteins
pigs
infection Streptococcus suis
ACTINOBACILLUS-PLEUROPNEUMONIAE INFECTION
C-REACTIVE PROTEIN
HAPTOGLOBIN CONCENTRATION
PREALBUMIN
STANDARDIZATION
INTERLEUKIN-6
MARKER
HEALTH
acute phase proteins
infection Streptococcus suis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig",

abstract = "Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.",

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author = "Campbell, {Fiona Margaret} and M Waterston and Andresen, {L O} and Sorensen, {N S} and Heegaard, {P M H} and Eckersall, {P D}",

year = "2005",

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T1 - The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

AU - Campbell, Fiona Margaret

AU - Waterston, M

AU - Andresen, L O

AU - Sorensen, N S

AU - Heegaard, P M H

AU - Eckersall, P D

PY - 2005

Y1 - 2005

N2 - Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

AB - Transthyretin (TTR) is a serum protein which is a negative acute phase reactant in humans and levels of TTR are routinely measured as an indicator of health status. Such tests have yet to be established for the pig. In order to measure serum TTR in the pig during an acute phase response an assay was developed using anti-human TTR antibodies which cross reacted with porcine TTR. The assay had a detection limit of 32 mu g/mL while the mean concentration of transthyretin measured in healthy pig serum was 302 +/- 8 mu g/mL ( n = 63). There was no significant difference in the serum concentration of TTR in three different age groups from 10 to 25 weeks. Following Streptococcus suis type 2 infection transthyretin showed a negative acute phase response with serum concentrations reaching a significantly lower level at two days following infection.

KW - acute phase proteins

KW - pigs

KW - infection Streptococcus suis

KW - ACTINOBACILLUS-PLEUROPNEUMONIAE INFECTION

KW - C-REACTIVE PROTEIN

KW - HAPTOGLOBIN CONCENTRATION

KW - PREALBUMIN

KW - STANDARDIZATION

KW - INTERLEUKIN-6

KW - MARKER

KW - HEALTH

KW - acute phase proteins

KW - infection Streptococcus suis

U2 - 10.1051/vetres:2005017

DO - 10.1051/vetres:2005017

M3 - Article

VL - 36

SP - 657

EP - 664

JO - Veterinary Research

JF - Veterinary Research

SN - 0928-4249

IS - 4

ER -

The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

Abstract

Keywords

UN SDGs

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