The neuropsychology of first impressions: Evidence from Huntington's disease

Reiner Sprengelmeyer (Corresponding Author), Andrew W. Young, Eva-Maria Baldas, Iris Ratheiser, Clare AM Sutherland, Hans-Peter Müller, Georg Grön, Sigurd D Süssmuth, G Bernhard Landwehrmeyer, Michael Orth

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Impairments of emotion recognition have been widely documented in Huntington's disease (HD), but little is known concerning how these relate to other aspects of social cognition, including first impressions of traits such as trustworthiness and dominance. Here, we introduce a novel and sensitive method to investigate the ability to evaluate trustworthiness and dominance from facial appearance, with control tasks measuring ability to perceive differences between comparable stimuli. We used this new method together with standard tests of face perception to investigate social cognition in HD. We found that a subgroup of people with HD was impaired at perceiving trustworthiness and dominance, and that perceiving trustworthiness and dominance were correlated with impaired facial expression recognition. In addition, we used diffusion tensor imaging (DTI) to provisionally identify candidate brain regions associated with social cognition by contrasting regional functional anisotropy (FA) measures between subgroups of HD participants showing normal or impaired perception of trustworthiness and dominance, and by correlating these regional brain abnormalities with behavioural performance on tests of emotion recognition. In this way we show for the first time alterations in perception of trustworthiness and dominance in people with HD and link these to regions which may map the boundaries of the social brain. The pattern of breakdown seen in this neurodegenerative disease can thus be used to explore potential inter-relationships between different components of social cognition.
Original languageEnglish
Pages (from-to)100-115
Number of pages16
JournalCortex
Volume85
Early online date21 Oct 2016
DOIs
Publication statusPublished - Dec 2016

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Neuropsychology
Huntington Disease
Cognition
Aptitude
Brain
Emotions
Facial Expression
Diffusion Tensor Imaging
Anisotropy
Neurodegenerative Diseases
Recognition (Psychology)

Keywords

  • Huntington's disease
  • trustworthiness
  • dominance
  • face perception
  • emotion recognition
  • DTI

Cite this

Sprengelmeyer, R., Young, A. W., Baldas, E-M., Ratheiser, I., Sutherland, C. AM., Müller, H-P., ... Orth, M. (2016). The neuropsychology of first impressions: Evidence from Huntington's disease. Cortex, 85, 100-115. https://doi.org/10.1016/j.cortex.2016.10.006

The neuropsychology of first impressions : Evidence from Huntington's disease. / Sprengelmeyer, Reiner (Corresponding Author); Young, Andrew W.; Baldas, Eva-Maria; Ratheiser, Iris; Sutherland, Clare AM; Müller, Hans-Peter; Grön, Georg; Süssmuth, Sigurd D; Landwehrmeyer, G Bernhard; Orth, Michael.

In: Cortex, Vol. 85, 12.2016, p. 100-115.

Research output: Contribution to journalArticle

Sprengelmeyer, R, Young, AW, Baldas, E-M, Ratheiser, I, Sutherland, CAM, Müller, H-P, Grön, G, Süssmuth, SD, Landwehrmeyer, GB & Orth, M 2016, 'The neuropsychology of first impressions: Evidence from Huntington's disease' Cortex, vol. 85, pp. 100-115. https://doi.org/10.1016/j.cortex.2016.10.006
Sprengelmeyer R, Young AW, Baldas E-M, Ratheiser I, Sutherland CAM, Müller H-P et al. The neuropsychology of first impressions: Evidence from Huntington's disease. Cortex. 2016 Dec;85:100-115. https://doi.org/10.1016/j.cortex.2016.10.006
Sprengelmeyer, Reiner ; Young, Andrew W. ; Baldas, Eva-Maria ; Ratheiser, Iris ; Sutherland, Clare AM ; Müller, Hans-Peter ; Grön, Georg ; Süssmuth, Sigurd D ; Landwehrmeyer, G Bernhard ; Orth, Michael. / The neuropsychology of first impressions : Evidence from Huntington's disease. In: Cortex. 2016 ; Vol. 85. pp. 100-115.
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