Abstract
The human genome codes for 48 members of the nuclear receptor superfamily, half of which have known ligands. Natural ligands for nuclear receptors are generally lipophilic in nature and include steroid hormones, bile acids, fatty acids, thyroid hormones, certain vitamins, and prostaglandins. Nuclear receptors regulate gene expression programs controlling development, differentiation, metabolic homeostasis and reproduction, in both a temporal and a tissue-selective manner. Since the original cloning of the cDNAs for the estrogen and glucocorticoid receptors, large strides have been made in our understanding of the structure and function of this family of transcription factors and their role in pathophysiology.
Original language | English |
---|---|
Pages (from-to) | 3-9 |
Number of pages | 7 |
Journal | Methods in Molecular Biology |
Volume | 1443 |
DOIs | |
Publication status | Published - 1 Jun 2016 |
Bibliographical note
The Nuclear Receptor Superfamily: Methods and Protocols: Part 1Print ISBN 978-1-4939-3722-6 Online ISBN 978-1-4939-3724-0
Keywords
- steroid hormones
- nuclear receptors
- gene expression
- allosteric regulations