The Nuclear Receptor Superfamily at Thirty

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9 Citations (Scopus)

Abstract

The human genome codes for 48 members of the nuclear receptor superfamily, half of which have known ligands. Natural ligands for nuclear receptors are generally lipophilic in nature and include steroid hormones, bile acids, fatty acids, thyroid hormones, certain vitamins, and prostaglandins. Nuclear receptors regulate gene expression programs controlling development, differentiation, metabolic homeostasis and reproduction, in both a temporal and a tissue-selective manner. Since the original cloning of the cDNAs for the estrogen and glucocorticoid receptors, large strides have been made in our understanding of the structure and function of this family of transcription factors and their role in pathophysiology.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalMethods in Molecular Biology
Volume1443
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • steroid hormones
  • nuclear receptors
  • gene expression
  • allosteric regulations

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