The origins of cyanobactin chemistry and biology

Marcel Jaspars*

*Corresponding author for this work

Research output: Contribution to journalEditorial

10 Citations (Scopus)

Abstract

The correct structure of the symmetrical cyanobactin, ascidiacyclamide, was published in Chemical Communications by Hamamoto et al. in 1983. The cyanobactin family of compounds are cyclic peptides with modifications including azole/azoline rings, D-stereocentres and in some cases prenyl groups. Although related compounds were isolated earlier by Ireland et al., two of the three published structures later had to be corrected. Hamamoto's ascidiacyclamide structure assisted the understanding of the chemistry, bioactivity, biological origin and biosynthesis of this group of compounds. Cyanobactins are of interest as new chemotypes for the treatment of a range of diseases, in particular those in which extended binding sites are implicated.

Original languageEnglish
Pages (from-to)10174-10176
Number of pages3
JournalChemical Communications
Volume50
Issue number71
Early online date23 Jul 2014
DOIs
Publication statusPublished - 14 Sep 2014

Keywords

  • tunicate lissoclinum-patella
  • cyclic-peptides
  • marine tunicate
  • macrocyclization
  • ascidiacyclamide
  • diversity
  • discovery
  • symbiont
  • pathway
  • route

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