The performance of CA-125 measurement in the detection of endometriosis: A meta-analysis

Ben W.J. Mol*, Neriman Bayram, Jeroen G. Lijmer, Maarten A.H.M. Wiegerinck, Marlies Y. Bongers, Fulco Van Der Veen, Patrick M.M. Bossuyt

*Corresponding author for this work

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Abstract

Objective: To assess the diagnostic performance of serum CA-125 measurement in the detection of endometriosis. Design: Meta-analysis. Setting and Patient(s): Twenty-three studies comparing serum CA-125 levels and laparoscopically confirmed endometriosis. Intervention(s): Serum CA-125 measurement and laparoscopy. Main Outcome Measure(s): Sensitivity and specificity of serum CA-125 measurement in the diagnosis of endometriosis with laparoscopy as the reference standard. Result(s): The estimated summary receiver operating characteristic curves showed that the performance of serum CA-125 measurement in the diagnosis of endometriosis grade I/IV is limited, whereas its performance in the diagnosis of endometriosis grade HI/IV is better. Conclusion(s): Despite its limited diagnostic performance, we believe that the routine use of serum CA-125 measurement in patients with infertility might be justified. In contrast to laparoscopy, serum CA-125 measurement is an inexpensive test that is not a burden for the patient. It could identify a subgroup of patients who are more likely to benefit from early laparoscopy. Studies reporting on the mutual dependence between serum CA-125 measurement and data from the history and physical examination are needed.

Original languageEnglish
Pages (from-to)1101-1108
Number of pages8
JournalFertility and Sterility
Volume70
Issue number6
DOIs
Publication statusPublished - 1 Dec 1998

Keywords

  • CA-125
  • Diagnosis
  • Endometriosis
  • Meta-analysis
  • Subfertility

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    Mol, B. W. J., Bayram, N., Lijmer, J. G., Wiegerinck, M. A. H. M., Bongers, M. Y., Van Der Veen, F., & Bossuyt, P. M. M. (1998). The performance of CA-125 measurement in the detection of endometriosis: A meta-analysis. Fertility and Sterility, 70(6), 1101-1108. https://doi.org/10.1016/S0015-0282(98)00355-0