The phospholipase A2 family's role in metabolic diseases: Focus on skeletal muscle

Iris Prunonosa Cervera, Brendan M Gabriel, Peter Aldiss, Nicholas M Morton* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The prevalence of obesity and type 2 diabetes has increased substantially in recent years creating a global health burden. In obesity, skeletal muscle, the main tissue responsible for insulin-mediated glucose uptake, exhibits dysregulation of insulin signaling, glucose uptake, lipid metabolism, and mitochondrial function, thus, promoting type 2 diabetes. The phospholipase A2 (PLA2) enzyme family mediates lipid signaling and membrane remodeling and may play an important role in metabolic disorders such as obesity, diabetes, hyperlipidemia, and fatty liver disease. The PLA2 family consists of 16 members clustered in four groups. PLA2s hydrolyze the sn-2 ester bond of phospholipids generating free fatty acids and lysophospholipids. Differential tissue and subcellular PLA2 expression patterns and the abundance of distinct fatty acyl groups in the target phospholipid determine the impact of individual family members on metabolic functions and, potentially, diseases. Here, we update the current knowledge of the role of the PLA2 family in skeletal muscle, with a view to their potential for therapeutic targeting in metabolic diseases.

Original languageEnglish
Article numbere14662
Number of pages11
JournalPhysiological reports
Volume9
Issue number1
Early online date12 Jan 2021
DOIs
Publication statusPublished - 12 Jan 2021

Keywords

  • obesity
  • phospholipase A2
  • skeletal muscle
  • type 2 diabetes

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