The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma

C M Shipman, K Vanderkerken, M J Rogers, J M Lippitt, K Asosingh, D E Hughes, B Van Camp, R G G Russell, P I Croucher

Research output: Contribution to journalArticle

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Abstract

Bisphosphonates are effective in the management of bone disease in patients with multiple myeloma and recent reports have suggested that they may also have an anti-tumour activity. In support of this, we have previously demonstrated that bisphosphonates can induce myeloma cell apoptosis in vitro; however, it remains unclear whether this occurs in vivo. We have therefore investigated the effect of the potent bisphosphonate ibandronate in the 5T2MM murine model of established multiple myeloma. Short-term treatment with a high dose of ibandronate had no effect on either myeloma cell number or the proportion of myeloma cells undergoing apoptosis. These observations suggest that although bisphosphonates induce apoptosis in myeloma cells in vitro, they may not have the same anti-tumour effects in vivo.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalBritish Journal of Haematology
Volume111
Publication statusPublished - 2000

Keywords

  • multiple myeloma
  • bisphosphonates
  • antitumour
  • bone disease
  • in vivo
  • SKELETAL EVENTS
  • PAMIDRONATE
  • LESIONS
  • MOUSE
  • 5T2

Cite this

Shipman, C. M., Vanderkerken, K., Rogers, M. J., Lippitt, J. M., Asosingh, K., Hughes, D. E., ... Croucher, P. I. (2000). The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma. British Journal of Haematology, 111, 283-286.

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma. / Shipman, C M ; Vanderkerken, K ; Rogers, M J ; Lippitt, J M ; Asosingh, K ; Hughes, D E ; Van Camp, B ; Russell, R G G ; Croucher, P I .

In: British Journal of Haematology, Vol. 111, 2000, p. 283-286.

Research output: Contribution to journalArticle

Shipman, CM, Vanderkerken, K, Rogers, MJ, Lippitt, JM, Asosingh, K, Hughes, DE, Van Camp, B, Russell, RGG & Croucher, PI 2000, 'The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma', British Journal of Haematology, vol. 111, pp. 283-286.
Shipman, C M ; Vanderkerken, K ; Rogers, M J ; Lippitt, J M ; Asosingh, K ; Hughes, D E ; Van Camp, B ; Russell, R G G ; Croucher, P I . / The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma. In: British Journal of Haematology. 2000 ; Vol. 111. pp. 283-286.
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T1 - The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma

AU - Shipman, C M

AU - Vanderkerken, K

AU - Rogers, M J

AU - Lippitt, J M

AU - Asosingh, K

AU - Hughes, D E

AU - Van Camp, B

AU - Russell, R G G

AU - Croucher, P I

PY - 2000

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N2 - Bisphosphonates are effective in the management of bone disease in patients with multiple myeloma and recent reports have suggested that they may also have an anti-tumour activity. In support of this, we have previously demonstrated that bisphosphonates can induce myeloma cell apoptosis in vitro; however, it remains unclear whether this occurs in vivo. We have therefore investigated the effect of the potent bisphosphonate ibandronate in the 5T2MM murine model of established multiple myeloma. Short-term treatment with a high dose of ibandronate had no effect on either myeloma cell number or the proportion of myeloma cells undergoing apoptosis. These observations suggest that although bisphosphonates induce apoptosis in myeloma cells in vitro, they may not have the same anti-tumour effects in vivo.

AB - Bisphosphonates are effective in the management of bone disease in patients with multiple myeloma and recent reports have suggested that they may also have an anti-tumour activity. In support of this, we have previously demonstrated that bisphosphonates can induce myeloma cell apoptosis in vitro; however, it remains unclear whether this occurs in vivo. We have therefore investigated the effect of the potent bisphosphonate ibandronate in the 5T2MM murine model of established multiple myeloma. Short-term treatment with a high dose of ibandronate had no effect on either myeloma cell number or the proportion of myeloma cells undergoing apoptosis. These observations suggest that although bisphosphonates induce apoptosis in myeloma cells in vitro, they may not have the same anti-tumour effects in vivo.

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KW - bisphosphonates

KW - antitumour

KW - bone disease

KW - in vivo

KW - SKELETAL EVENTS

KW - PAMIDRONATE

KW - LESIONS

KW - MOUSE

KW - 5T2

M3 - Article

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SP - 283

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JO - British Journal of Haematology

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