The Potential Effects of Polyunsaturated ω-3 Fatty Acids on Spinal Cord Injury: A Systematic Review & Meta-Analysis of Preclinical Evidence

William Andrew Macintosh-Smith; Aya Mohamed Faisal Abdallah; Catriona Cunningham

doi:10.1016/j.plefa.2023.102554

The Potential Effects of Polyunsaturated ω-3 Fatty Acids on Spinal Cord Injury: A Systematic Review & Meta-Analysis of Preclinical Evidence

William Andrew Macintosh-Smith^* (Corresponding Author), Aya Mohamed Faisal Abdallah, Catriona Cunningham

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Polyunsaturated fatty acids (PUFAs) have received attention for their anti-inflammatory and antioxidant properties. Preclinical studies have investigated the efficacy of PUFAs in animal models of spinal cord injury (SCI) to determine if these properties can translate to neuroprotection and locomotor recovery. Findings from such studies have been promising, suggesting PUFAs as potential treatments against the neurological dysfunction induced by SCI. This systematic review and meta-analysis sought to investigate the efficacy of PUFAs for promoting locomotor recovery in animal models of SCI. PubMed, Web of Science and Embase (Ovid) were searched for relevant papers and those that examined the restorative effects of PUFAs on locomotor recovery in preclinical SCI models were included in our analysis. A random effects meta-analysis (restricted maximum likelihood estimator) was employed. A total of 28 studies were included and the results showed the claim that PUFAs have a beneficial therapeutic effect for promoting locomotor recovery (SMD = 1.037, 95% CI = 0.809–1.2644, p =

Original language	English
Article number	102554
Number of pages	10
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume	191
Early online date	12 Mar 2023
DOIs	https://doi.org/10.1016/j.plefa.2023.102554
Publication status	Published - 1 Apr 2023

Bibliographical note

Acknowledgements
We would like to thank Dr Wenlong Huang for his diligent assistance and detailed guidance that helped in the synthesis of this paper. We would also thank Dr Ping Yip for his assistance in providing missing information for studies he authored that were included in our systematic review and meta-analysis
Funding sources
The written content of this article was supported by the Elphinstone Scholarship (the University of Aberdeen); the Scottish Rugby Union and the Development Trust (the University of Aberdeen).

Keywords

Spinal cord injury
Omega-3 fatty acids
Systematic review
meta-Analysis
Cell Survival
Locomotor recovery

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The Potential Effects of Polyunsaturated ω-3 Fatty Acids on Spinal Cord Injury: A Systematic Review & Meta-Analysis of Preclinical Evidence. / Macintosh-Smith, William Andrew (Corresponding Author); Abdallah, Aya Mohamed Faisal; Cunningham, Catriona.
In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 191, 102554, 01.04.2023.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Polyunsaturated fatty acids (PUFAs) have received attention for their anti-inflammatory and antioxidant properties. Preclinical studies have investigated the efficacy of PUFAs in animal models of spinal cord injury (SCI) to determine if these properties can translate to neuroprotection and locomotor recovery. Findings from such studies have been promising, suggesting PUFAs as potential treatments against the neurological dysfunction induced by SCI. This systematic review and meta-analysis sought to investigate the efficacy of PUFAs for promoting locomotor recovery in animal models of SCI. PubMed, Web of Science and Embase (Ovid) were searched for relevant papers and those that examined the restorative effects of PUFAs on locomotor recovery in preclinical SCI models were included in our analysis. A random effects meta-analysis (restricted maximum likelihood estimator) was employed. A total of 28 studies were included and the results showed the claim that PUFAs have a beneficial therapeutic effect for promoting locomotor recovery (SMD = 1.037, 95% CI = 0.809–1.2644, p = ",

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The Potential Effects of Polyunsaturated ω-3 Fatty Acids on Spinal Cord Injury: A Systematic Review & Meta-Analysis of Preclinical Evidence

Abstract

Bibliographical note

Keywords

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