The potential role of adult stem cells in the management of the rheumatic diseases

Tiziana Franceschetti, Cosimo De Bari

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Adult stem cells are considered as appealing therapeutic candidates for inflammatory and degenerative musculoskeletal diseases. A large body of preclinical research has contributed to describing their immune-modulating properties and regenerative potential. Additionally, increasing evidence suggests that stem cell differentiation and function are disrupted in the pathogenesis of rheumatic diseases. Clinical studies have been limited, for the most part, to the application of adult stem cell-based treatments on small numbers of patients or as a 'salvage' therapy in life-threatening disease cases. Nevertheless, these preliminary studies indicate that adult stem cells are promising tools for the long-term treatment of rheumatic diseases. This review highlights recent knowledge acquired in the fields of hematopoietic and mesenchymal stem cell therapy for the management of systemic sclerosis (SSc), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and osteoarthritis (OA) and the potential mechanisms mediating their function.

Original languageEnglish
Pages (from-to)165-179
Number of pages15
JournalTherapeutic advances in musculoskeletal disease
Volume9
Issue number7
Early online date20 Apr 2017
DOIs
Publication statusPublished - Jul 2017

Keywords

  • stem cells
  • arthritis
  • rheumatic diseases
  • immune modulation
  • cartilage repair
  • cell therapy
  • regenerative medicine

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