The potential roles of sphingolipids in vascular smooth-muscle function

G. F. Nixon (Corresponding Author), F. A. Mathieson, I. Hunter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Increasing experimental evidence has demonstrated that sphingolipids are likely to have an important regulatory function in the cardiovascular system. Two sphingolipids released from activated platelets, and therefore of particular relevance, are S1P (sphingosine 1-phosphate) and SPC (sphingosylphosphocholine). Both S1P and SPC can act as vasoconstrictors and may modulate VSMC (vascular smooth muscle cell) phenotype, as observed during the pathogenesis of vascular disease. Recent research has suggested that SPC may act as a pro-inflammatory mediator in VSMCs and, in some circumstances, may also contribute to the development of vascular disease.

Original languageEnglish
Pages (from-to)908-909
Number of pages2
JournalBiochemical Society Transactions
Volume35
Issue number5
DOIs
Publication statusPublished - 2007

Keywords

  • inflammation
  • sphingolipid
  • vascular disease
  • vascular smooth muscle cell (VSMC)
  • vasoconstriction
  • sphingosine-1-phosphate
  • receptors
  • sphingosylphosphorylcholine
  • CA2+

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