The presentation and clinical course of intracranial developmental venous anomalies in adults

Jennifer M L Hon, Jo J Bhattacharya, Carl E Counsell, Vakis Papanastassiou, Vaughn Ritchie, Richard C Roberts, Robin J Sellar, Charles P Warlow, Rustam Al-Shahi Salman, SIVMS Collaborators

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37 Citations (Scopus)

Abstract

Background and Purpose— Reported risks of hemorrhage from intracranial developmental venous anomalies (DVAs) vary, so we investigated this in a systematic review and population-based study.

Methods— We systematically reviewed the literature (Ovid Medline and Embase to November 7, 2007) and selected studies of ≥20 participants with ≥1 DVA(s) that described their clinical presentation and/or their clinical course over a specified follow-up period. We also identified every adult first diagnosed with a DVA in Scotland from 1999 to 2003 and followed them in a prospective, population-based study.

Results— Of 2068 articles detected by the literature search, 15 met our inclusion criteria and described clinical presentation, 8 of which also described the clinical course of DVAs. In the 15 studies of 714 people first presenting with a DVA, 61% were incidental findings, the mode of presentation was unclear in 23%, 6% presented with nonhemorrhagic focal neurological deficit, 6% had caused symptomatic hemorrhage, 4% were associated with epileptic seizure, and <1% were associated with infarction. In studies of the clinical course of 422 people with a DVA, the hemorrhage rate after first presentation ranged from 0% to 1.28% per year. In the population-based study of 93 adults with DVAs, 98% were incidental, 1% presented with symptomatic hemorrhage, and 1% presented with an infarct, but there were no symptomatic hemorrhages or infarcts in 492 person-years of follow-up (0% per person-year; 95% CI, 0% to 0.7%).

Conclusions— Intracranial DVAs have a benign presentation and clinical course.
Original languageEnglish
Pages (from-to)1980-1985
Number of pages6
JournalStroke
Volume40
Issue number6
Early online date23 Apr 2009
DOIs
Publication statusPublished - Jun 2009

Keywords

  • adult
  • aged
  • aged, 80 and over
  • cerebral Hemorrhage
  • cerebral infarction
  • cognition disorders
  • female
  • follow-up studies
  • humans
  • intracranial arteriovenous malformations
  • magnetic resonance imaging
  • male
  • middle aged
  • population
  • prospective studies
  • Scotland
  • seizures
  • treatment outcome
  • young adult

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  • Cite this

    Hon, J. M. L., Bhattacharya, J. J., Counsell, C. E., Papanastassiou, V., Ritchie, V., Roberts, R. C., Sellar, R. J., Warlow, C. P., Al-Shahi Salman, R., & SIVMS Collaborators (2009). The presentation and clinical course of intracranial developmental venous anomalies in adults. Stroke, 40(6), 1980-1985. https://doi.org/10.1161/STROKEAHA.108.533034