The prevalence of progressive supranuclear palsy and corticobasal syndrome in Scotland

Diane Swallow* (Corresponding Author), Carl Counsell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction We estimated the point prevalence of progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) at regional and national levels in Scotland, UK as there are few high-quality prevalence studies of these conditions. Methods Nationally, multiple methods of case ascertainment were used including clinician and nurse specialist referral, searches of ICD-10 diagnostic coding in routinely collected electronic health data (Scottish Morbidity Record), and patient self-referral. In one region we also searched GP databases and unselected hospital correspondence. Cases were verified by clinical examination or medical record review. National and regional total and age-sex stratified crude prevalence rates on 31st December 2018 were calculated. Results The regional crude point prevalence was 4.28 per 100,000 (95% CI 2.90, 6.31) for PSP, and 2.05 per 100,000 (95% CI 1.17, 3.59) for CBS. The national crude prevalence rates were lower due to the greater reliance on passive case ascertainment. There were no clear sex differences. At a national level, the peak crude prevalence rate for both PSP and CBS was in the 70-79 age-group. Discussion The prevalence rates of PSP and CBS were similar to previous estimates with little change over the past 20 years.

Original languageEnglish
JournalNeuroepidemiology
Early online date2 Jun 2022
DOIs
Publication statusE-pub ahead of print - 2 Jun 2022

Keywords

  • progressive supranuclear palsy
  • corticobasal degeneration
  • corticobasal syndrome
  • prevalence
  • epidemiology

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