The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer

Mahdi Rivandi; Alireza Pasdar; Leila Hamzezadeh; Amir Tajbakhsh; Sima Seifi; Mehrdad Moetamani-Ahmadi; Gordon A. Ferns; Amir Avan

doi:10.1002/jcp.27136

The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer

Mahdi Rivandi, Alireza Pasdar, Leila Hamzezadeh, Amir Tajbakhsh, Sima Seifi, Mehrdad Moetamani-Ahmadi, Gordon A. Ferns, Amir Avan^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Long noncoding RNAs (lncRNAs) consist of 200 nucleotide sequences that play essential roles in different processes, including cell proliferation, and differentiation. There is evidence showing that the dysregulation of lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR) leads to the development and progression in several cancers including colorectal cancer, via p53-dependent manner. This suggests that these lncRNAs may be of value as prognostic indices and a therapeutic target, as a high expression of lncRNAs PANDAR is associated with poor prognosis. Furthermore, modulating lncRNAs PANDAR has been reported to induce apoptosis and inhibit the tumor growth through modulation of cell cycle and epithelial-mesenchymal transition (EMT) pathway. The aim of the current review was to provide an overview of the prognostic and therapeutic values of lncRNAs PANDAR in colorectal cancer.

Original language	English
Pages (from-to)	1230-1236
Number of pages	7
Journal	Journal of Cellular Physiology
Volume	234
Issue number	2
Early online date	7 Sep 2018
DOIs	https://doi.org/10.1002/jcp.27136
Publication status	Published - 1 Feb 2019

Keywords

colorectal cancer
lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR)
long noncoding RNAs (lncRNAs)
prognostic biomarker
therapeutic target

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer",

abstract = "Long noncoding RNAs (lncRNAs) consist of 200 nucleotide sequences that play essential roles in different processes, including cell proliferation, and differentiation. There is evidence showing that the dysregulation of lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR) leads to the development and progression in several cancers including colorectal cancer, via p53-dependent manner. This suggests that these lncRNAs may be of value as prognostic indices and a therapeutic target, as a high expression of lncRNAs PANDAR is associated with poor prognosis. Furthermore, modulating lncRNAs PANDAR has been reported to induce apoptosis and inhibit the tumor growth through modulation of cell cycle and epithelial-mesenchymal transition (EMT) pathway. The aim of the current review was to provide an overview of the prognostic and therapeutic values of lncRNAs PANDAR in colorectal cancer.",

keywords = "colorectal cancer, lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR), long noncoding RNAs (lncRNAs), prognostic biomarker, therapeutic target",

author = "Mahdi Rivandi and Alireza Pasdar and Leila Hamzezadeh and Amir Tajbakhsh and Sima Seifi and Mehrdad Moetamani-Ahmadi and Ferns, {Gordon A.} and Amir Avan",

note = "ACKNOWLEDGMENT: This work was supported by a grant from National Institute for Medical research Development, Grant No. 962782 (A. Avan). ",

year = "2019",

month = feb,

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doi = "10.1002/jcp.27136",

language = "English",

volume = "234",

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TY - JOUR

T1 - The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer

AU - Rivandi, Mahdi

AU - Pasdar, Alireza

AU - Hamzezadeh, Leila

AU - Tajbakhsh, Amir

AU - Seifi, Sima

AU - Moetamani-Ahmadi, Mehrdad

AU - Ferns, Gordon A.

AU - Avan, Amir

N1 - ACKNOWLEDGMENT: This work was supported by a grant from National Institute for Medical research Development, Grant No. 962782 (A. Avan).

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Long noncoding RNAs (lncRNAs) consist of 200 nucleotide sequences that play essential roles in different processes, including cell proliferation, and differentiation. There is evidence showing that the dysregulation of lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR) leads to the development and progression in several cancers including colorectal cancer, via p53-dependent manner. This suggests that these lncRNAs may be of value as prognostic indices and a therapeutic target, as a high expression of lncRNAs PANDAR is associated with poor prognosis. Furthermore, modulating lncRNAs PANDAR has been reported to induce apoptosis and inhibit the tumor growth through modulation of cell cycle and epithelial-mesenchymal transition (EMT) pathway. The aim of the current review was to provide an overview of the prognostic and therapeutic values of lncRNAs PANDAR in colorectal cancer.

AB - Long noncoding RNAs (lncRNAs) consist of 200 nucleotide sequences that play essential roles in different processes, including cell proliferation, and differentiation. There is evidence showing that the dysregulation of lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR) leads to the development and progression in several cancers including colorectal cancer, via p53-dependent manner. This suggests that these lncRNAs may be of value as prognostic indices and a therapeutic target, as a high expression of lncRNAs PANDAR is associated with poor prognosis. Furthermore, modulating lncRNAs PANDAR has been reported to induce apoptosis and inhibit the tumor growth through modulation of cell cycle and epithelial-mesenchymal transition (EMT) pathway. The aim of the current review was to provide an overview of the prognostic and therapeutic values of lncRNAs PANDAR in colorectal cancer.

KW - colorectal cancer

KW - lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR)

KW - long noncoding RNAs (lncRNAs)

KW - prognostic biomarker

KW - therapeutic target

UR - http://www.scopus.com/inward/record.url?scp=85052926942&partnerID=8YFLogxK

U2 - 10.1002/jcp.27136

DO - 10.1002/jcp.27136

M3 - Review article

C2 - 30191971

AN - SCOPUS:85052926942

VL - 234

SP - 1230

EP - 1236

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

IS - 2

ER -

The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer

Abstract

Keywords

UN SDGs

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