The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation: A study protocol for the meta-analysis of individual patient data

N. M. van den Boogaard, P. G. A. Hompes, K. Barnhart, Siladitya Bhattacharya, I. M. Custers, C. Coutifaris, A. J. Goverde, D. S. Guzick, P. F. Litvak, P. N. Steures, F. van der Veen, P. Bossuyt, B. W. J. Mol

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective The current evidence concerning the best treatment option for couples with unexplained and male subfertility is inconclusive. Most studies that have evaluated the effectiveness of treatment options, such as expectant management (EM), intrauterine insemination (IUI), with or without controlled ovarian stimulation (COS), and in vitro fertilisation (IVF), have not taken the couples’ prognosis into account. It is very likely that the individual prognosis of the couple influences the effect of treatment. Individual patient data analyses allow us to take these prognostic factors into account, and to evaluate their effect on treatment outcome. This study aims to use anonymised data from relevant published trials to perform an individual patient data meta-analysis, evaluating the effect of couples’ prognosis on the effectiveness of EM, IUI, with or without COS, and IVF.

Methods Based on earlier systematic reviews and an updated search, randomised controlled trials will be considered for inclusion. Untreated subfertile couples with unexplained or male subfertility included in trials comparing EM, IUI, with or without COS, and IVF are included. Authors of the included studies will be invited to share their original anonymised data. The data will be assessed on validity, quality and completeness. The prognosis of the individual couple will be calculated with existing prognostic models. The effect of the prognosis on treatment outcome will be analysed with marker-by-treatment predictiveness curves, illustrating the effect of prognosis on treatment outcome. This study is registered in PROSPERO (registration number CRD42011001832).

Conclusion Ultimately, this study may help to select the appropriate fertility treatment, tailored to the needs of an individual couple.
Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalBJOG-An International Journal of Obstetrics and Gynaecology
Volume119
Issue number8
Early online date18 May 2012
DOIs
Publication statusPublished - Jul 2012

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Insemination
Fertilization in Vitro
Meta-Analysis
Ovulation Induction
Male Infertility
Therapeutics
Fertility
Randomized Controlled Trials

Keywords

  • expectant management
  • in vitro fertilisation
  • intrauterine insemination
  • prognostic models
  • subfertility

Cite this

The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation : A study protocol for the meta-analysis of individual patient data. / van den Boogaard, N. M.; Hompes, P. G. A.; Barnhart, K.; Bhattacharya, Siladitya; Custers, I. M.; Coutifaris, C.; Goverde, A. J.; Guzick, D. S.; Litvak, P. F.; Steures, P. N.; van der Veen, F.; Bossuyt, P.; Mol, B. W. J.

In: BJOG-An International Journal of Obstetrics and Gynaecology, Vol. 119, No. 8, 07.2012, p. 953-957.

Research output: Contribution to journalArticle

van den Boogaard, N. M. ; Hompes, P. G. A. ; Barnhart, K. ; Bhattacharya, Siladitya ; Custers, I. M. ; Coutifaris, C. ; Goverde, A. J. ; Guzick, D. S. ; Litvak, P. F. ; Steures, P. N. ; van der Veen, F. ; Bossuyt, P. ; Mol, B. W. J. / The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation : A study protocol for the meta-analysis of individual patient data. In: BJOG-An International Journal of Obstetrics and Gynaecology. 2012 ; Vol. 119, No. 8. pp. 953-957.
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abstract = "Objective The current evidence concerning the best treatment option for couples with unexplained and male subfertility is inconclusive. Most studies that have evaluated the effectiveness of treatment options, such as expectant management (EM), intrauterine insemination (IUI), with or without controlled ovarian stimulation (COS), and in vitro fertilisation (IVF), have not taken the couples’ prognosis into account. It is very likely that the individual prognosis of the couple influences the effect of treatment. Individual patient data analyses allow us to take these prognostic factors into account, and to evaluate their effect on treatment outcome. This study aims to use anonymised data from relevant published trials to perform an individual patient data meta-analysis, evaluating the effect of couples’ prognosis on the effectiveness of EM, IUI, with or without COS, and IVF. Methods Based on earlier systematic reviews and an updated search, randomised controlled trials will be considered for inclusion. Untreated subfertile couples with unexplained or male subfertility included in trials comparing EM, IUI, with or without COS, and IVF are included. Authors of the included studies will be invited to share their original anonymised data. The data will be assessed on validity, quality and completeness. The prognosis of the individual couple will be calculated with existing prognostic models. The effect of the prognosis on treatment outcome will be analysed with marker-by-treatment predictiveness curves, illustrating the effect of prognosis on treatment outcome. This study is registered in PROSPERO (registration number CRD42011001832). Conclusion Ultimately, this study may help to select the appropriate fertility treatment, tailored to the needs of an individual couple.",
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T1 - The prognostic profile of subfertile couples and treatment outcome after expectant management, intrauterine insemination and in vitro fertilisation

T2 - A study protocol for the meta-analysis of individual patient data

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AU - Hompes, P. G. A.

AU - Barnhart, K.

AU - Bhattacharya, Siladitya

AU - Custers, I. M.

AU - Coutifaris, C.

AU - Goverde, A. J.

AU - Guzick, D. S.

AU - Litvak, P. F.

AU - Steures, P. N.

AU - van der Veen, F.

AU - Bossuyt, P.

AU - Mol, B. W. J.

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N2 - Objective The current evidence concerning the best treatment option for couples with unexplained and male subfertility is inconclusive. Most studies that have evaluated the effectiveness of treatment options, such as expectant management (EM), intrauterine insemination (IUI), with or without controlled ovarian stimulation (COS), and in vitro fertilisation (IVF), have not taken the couples’ prognosis into account. It is very likely that the individual prognosis of the couple influences the effect of treatment. Individual patient data analyses allow us to take these prognostic factors into account, and to evaluate their effect on treatment outcome. This study aims to use anonymised data from relevant published trials to perform an individual patient data meta-analysis, evaluating the effect of couples’ prognosis on the effectiveness of EM, IUI, with or without COS, and IVF. Methods Based on earlier systematic reviews and an updated search, randomised controlled trials will be considered for inclusion. Untreated subfertile couples with unexplained or male subfertility included in trials comparing EM, IUI, with or without COS, and IVF are included. Authors of the included studies will be invited to share their original anonymised data. The data will be assessed on validity, quality and completeness. The prognosis of the individual couple will be calculated with existing prognostic models. The effect of the prognosis on treatment outcome will be analysed with marker-by-treatment predictiveness curves, illustrating the effect of prognosis on treatment outcome. This study is registered in PROSPERO (registration number CRD42011001832). Conclusion Ultimately, this study may help to select the appropriate fertility treatment, tailored to the needs of an individual couple.

AB - Objective The current evidence concerning the best treatment option for couples with unexplained and male subfertility is inconclusive. Most studies that have evaluated the effectiveness of treatment options, such as expectant management (EM), intrauterine insemination (IUI), with or without controlled ovarian stimulation (COS), and in vitro fertilisation (IVF), have not taken the couples’ prognosis into account. It is very likely that the individual prognosis of the couple influences the effect of treatment. Individual patient data analyses allow us to take these prognostic factors into account, and to evaluate their effect on treatment outcome. This study aims to use anonymised data from relevant published trials to perform an individual patient data meta-analysis, evaluating the effect of couples’ prognosis on the effectiveness of EM, IUI, with or without COS, and IVF. Methods Based on earlier systematic reviews and an updated search, randomised controlled trials will be considered for inclusion. Untreated subfertile couples with unexplained or male subfertility included in trials comparing EM, IUI, with or without COS, and IVF are included. Authors of the included studies will be invited to share their original anonymised data. The data will be assessed on validity, quality and completeness. The prognosis of the individual couple will be calculated with existing prognostic models. The effect of the prognosis on treatment outcome will be analysed with marker-by-treatment predictiveness curves, illustrating the effect of prognosis on treatment outcome. This study is registered in PROSPERO (registration number CRD42011001832). Conclusion Ultimately, this study may help to select the appropriate fertility treatment, tailored to the needs of an individual couple.

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KW - in vitro fertilisation

KW - intrauterine insemination

KW - prognostic models

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JO - BJOG-An International Journal of Obstetrics and Gynaecology

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SN - 1470-0328

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