Methods Based on earlier systematic reviews and an updated search, randomised controlled trials will be considered for inclusion. Untreated subfertile couples with unexplained or male subfertility included in trials comparing EM, IUI, with or without COS, and IVF are included. Authors of the included studies will be invited to share their original anonymised data. The data will be assessed on validity, quality and completeness. The prognosis of the individual couple will be calculated with existing prognostic models. The effect of the prognosis on treatment outcome will be analysed with marker-by-treatment predictiveness curves, illustrating the effect of prognosis on treatment outcome. This study is registered in PROSPERO (registration number CRD42011001832).
Conclusion Ultimately, this study may help to select the appropriate fertility treatment, tailored to the needs of an individual couple.
|Number of pages||5|
|Journal||BJOG-An International Journal of Obstetrics and Gynaecology|
|Early online date||18 May 2012|
|Publication status||Published - Jul 2012|
- expectant management
- in vitro fertilisation
- intrauterine insemination
- prognostic models