The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

G. V. Narayansingh; Iain D Miller; M Sharma; C. J. Welch; Linda Sharp; D. E. Parkin; Margaret Eleanor Cruickshank

doi:10.1038/sj.bjc.6602343

The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

G. V. Narayansingh, Iain D Miller, M Sharma, C. J. Welch, Linda Sharp, D. E. Parkin, Margaret Eleanor Cruickshank

School of Medicine, Medical Sciences & Nutrition

Aberdeen Royal Infirmary

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

Original language	English
Pages (from-to)	222-224
Number of pages	2
Journal	British Journal of Cancer
Volume	92
DOIs	https://doi.org/10.1038/sj.bjc.6602343
Publication status	Published - 2005

Keywords

vulval cancer
groin nodes
micrometastases
SENTINEL LYMPH-NODE
GROIN RECURRENCE
CERVICAL-CANCER

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6602343

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title = "The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva",

abstract = "Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).",

keywords = "vulval cancer, groin nodes, micrometastases, SENTINEL LYMPH-NODE, GROIN RECURRENCE, CERVICAL-CANCER",

author = "Narayansingh, {G. V.} and Miller, {Iain D} and M Sharma and Welch, {C. J.} and Linda Sharp and Parkin, {D. E.} and Cruickshank, {Margaret Eleanor}",

year = "2005",

doi = "10.1038/sj.bjc.6602343",

language = "English",

volume = "92",

pages = "222--224",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

AU - Narayansingh, G. V.

AU - Miller, Iain D

AU - Sharma, M

AU - Welch, C. J.

AU - Sharp, Linda

AU - Parkin, D. E.

AU - Cruickshank, Margaret Eleanor

PY - 2005

Y1 - 2005

N2 - Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

AB - Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

KW - vulval cancer

KW - groin nodes

KW - micrometastases

KW - SENTINEL LYMPH-NODE

KW - GROIN RECURRENCE

KW - CERVICAL-CANCER

U2 - 10.1038/sj.bjc.6602343

DO - 10.1038/sj.bjc.6602343

M3 - Article

SN - 0007-0920

VL - 92

SP - 222

EP - 224

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

Abstract

Keywords

UN SDGs

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