The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

G. V. Narayansingh, Iain D Miller, M Sharma, C. J. Welch, Linda Sharp, D. E. Parkin, Margaret Eleanor Cruickshank

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

    Original languageEnglish
    Pages (from-to)222-224
    Number of pages2
    JournalBritish Journal of Cancer
    Volume92
    DOIs
    Publication statusPublished - 2005

    Keywords

    • vulval cancer
    • groin nodes
    • micrometastases
    • SENTINEL LYMPH-NODE
    • GROIN RECURRENCE
    • CERVICAL-CANCER

    Cite this

    The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva. / Narayansingh, G. V.; Miller, Iain D; Sharma, M; Welch, C. J.; Sharp, Linda; Parkin, D. E.; Cruickshank, Margaret Eleanor.

    In: British Journal of Cancer, Vol. 92, 2005, p. 222-224.

    Research output: Contribution to journalArticle

    Narayansingh, G. V. ; Miller, Iain D ; Sharma, M ; Welch, C. J. ; Sharp, Linda ; Parkin, D. E. ; Cruickshank, Margaret Eleanor. / The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva. In: British Journal of Cancer. 2005 ; Vol. 92. pp. 222-224.
    @article{fe14c406089f459ba8e6aaadec76b631,
    title = "The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva",
    abstract = "Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42{\%}) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95{\%} CI 2.3 - 171).",
    keywords = "vulval cancer, groin nodes, micrometastases, SENTINEL LYMPH-NODE, GROIN RECURRENCE, CERVICAL-CANCER",
    author = "Narayansingh, {G. V.} and Miller, {Iain D} and M Sharma and Welch, {C. J.} and Linda Sharp and Parkin, {D. E.} and Cruickshank, {Margaret Eleanor}",
    year = "2005",
    doi = "10.1038/sj.bjc.6602343",
    language = "English",
    volume = "92",
    pages = "222--224",
    journal = "British Journal of Cancer",
    issn = "0007-0920",
    publisher = "Nature Publishing Group",

    }

    TY - JOUR

    T1 - The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

    AU - Narayansingh, G. V.

    AU - Miller, Iain D

    AU - Sharma, M

    AU - Welch, C. J.

    AU - Sharp, Linda

    AU - Parkin, D. E.

    AU - Cruickshank, Margaret Eleanor

    PY - 2005

    Y1 - 2005

    N2 - Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

    AB - Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

    KW - vulval cancer

    KW - groin nodes

    KW - micrometastases

    KW - SENTINEL LYMPH-NODE

    KW - GROIN RECURRENCE

    KW - CERVICAL-CANCER

    U2 - 10.1038/sj.bjc.6602343

    DO - 10.1038/sj.bjc.6602343

    M3 - Article

    VL - 92

    SP - 222

    EP - 224

    JO - British Journal of Cancer

    JF - British Journal of Cancer

    SN - 0007-0920

    ER -