The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

G. V. Narayansingh, Iain D Miller, M Sharma, C. J. Welch, Linda Sharp, D. E. Parkin, Margaret Eleanor Cruickshank

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    Abstract

    Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).

    Original languageEnglish
    Pages (from-to)222-224
    Number of pages2
    JournalBritish Journal of Cancer
    Volume92
    DOIs
    Publication statusPublished - 2005

    Keywords

    • vulval cancer
    • groin nodes
    • micrometastases
    • SENTINEL LYMPH-NODE
    • GROIN RECURRENCE
    • CERVICAL-CANCER

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